GSM8077552

Dataset: gse255685 • Sample: YZ631 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 43.2%ile (≈ Median)
22,355 Genes with score > 0 Group median: 22,378 • 19.7%ile (↓ Low)
0 Median expression score Group median: 0 • 9.1%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

57.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.05
bar=donor   line=cohort median 		2.02 55.4%
FOXO3 Insulin/IGF-1 Signaling 10.02
bar=donor   line=cohort median 		9.99 54.3%
CETP Lipid Metabolism 5.44
bar=donor   line=cohort median 		5.05 88.7%
SIRT6 Sirtuin Family 8.25
bar=donor   line=cohort median 		8.34 29.2%
SIRT1 Sirtuin Family 8.90
bar=donor   line=cohort median 		8.72 82.6%
SIRT3 Sirtuin Family 7.51
bar=donor   line=cohort median 		7.49 55.0%
IGF1R Insulin/IGF-1 Signaling 10.66
bar=donor   line=cohort median 		10.21 92.7%
KLOTHO Anti-aging 2.91
bar=donor   line=cohort median 		2.51 92.7%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 83.7%
IL6 Inflammation 1.33
bar=donor   line=cohort median 		1.16 81.9%
TERT Telomere Maintenance 1.31
bar=donor   line=cohort median 		1.51 9.5%
IRS2 Insulin/IGF-1 Signaling 9.63
bar=donor   line=cohort median 		9.81 31.7%
TP53 Tumor Suppression 8.80
bar=donor   line=cohort median 		8.92 38.5%
SHC1 Signal Transduction 9.11
bar=donor   line=cohort median 		9.35 2.3%
ACE Signal Transduction 4.84
bar=donor   line=cohort median 		4.64 70.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.9 0
2 B2M 17.1 0
3 EEF1A1 16.7 0
4 ACTB 16.5 0
5 MT-CO1 16.4 0
6 MT-RNR1 16.3 0
7 HLA-C 16.2 0
8 S100A9 16.0 0
9 HLA-B 15.9 0
10 FTL 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.1
bar=donor   line=cohort median 		14.2 14.2 94.4%
2 S100A9 16.0
bar=donor   line=cohort median 		15.4 15.5 80.1%
3 IL1B 10.3
bar=donor   line=cohort median 		9.5 9.3 94.8%
4 CXCL8 9.0
bar=donor   line=cohort median 		10.3 11.4 11.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.7
bar=donor   line=cohort median 		6.1 6.1 14.5%
6 FCGR3B 14.9
bar=donor   line=cohort median 		14.7 14.7 67.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 71.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 41.0%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 23.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 59.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.5 11.7 37.8%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 68.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 42.1%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 56.5%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 64.3%
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