GSM8077553

Dataset: gse255685 • Sample: YZ633 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 59.7%ile (≈ Median)
22,387 Genes with score > 0 Group median: 22,378 • 64.0%ile (≈ Median)
0 Median expression score Group median: 0 • 40.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

36.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.16
bar=donor   line=cohort median 		2.02 71.2%
FOXO3 Insulin/IGF-1 Signaling 9.75
bar=donor   line=cohort median 		9.99 20.3%
CETP Lipid Metabolism 4.92
bar=donor   line=cohort median 		5.05 35.7%
SIRT6 Sirtuin Family 8.27
bar=donor   line=cohort median 		8.34 33.9%
SIRT1 Sirtuin Family 8.39
bar=donor   line=cohort median 		8.72 10.2%
SIRT3 Sirtuin Family 7.60
bar=donor   line=cohort median 		7.49 69.4%
IGF1R Insulin/IGF-1 Signaling 9.99
bar=donor   line=cohort median 		10.21 31.0%
KLOTHO Anti-aging 2.57
bar=donor   line=cohort median 		2.51 60.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 41.4%
IL6 Inflammation 1.32
bar=donor   line=cohort median 		1.16 79.4%
TERT Telomere Maintenance 1.37
bar=donor   line=cohort median 		1.51 17.4%
IRS2 Insulin/IGF-1 Signaling 9.29
bar=donor   line=cohort median 		9.81 7.7%
TP53 Tumor Suppression 8.77
bar=donor   line=cohort median 		8.92 34.2%
SHC1 Signal Transduction 9.07
bar=donor   line=cohort median 		9.35 1.6%
ACE Signal Transduction 4.54
bar=donor   line=cohort median 		4.64 39.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 16.9 0
3 EEF1A1 16.9 0
4 ACTB 16.5 0
5 MT-CO1 16.4 0
6 HLA-C 16.0 0
7 HLA-B 15.8 0
8 MT-RNR1 15.8 0
9 S100A9 15.7 0
10 HLA-E 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.7
bar=donor   line=cohort median 		14.2 14.2 84.4%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 66.1%
3 IL1B 8.8
bar=donor   line=cohort median 		9.5 9.3 27.1%
4 CXCL8 11.8
bar=donor   line=cohort median 		10.3 11.4 60.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.8
bar=donor   line=cohort median 		6.1 6.1 94.1%
6 FCGR3B 14.3
bar=donor   line=cohort median 		14.7 14.7 18.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.1
bar=donor   line=cohort median 		14.4 14.3 30.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 63.3%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 40.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 46.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 26.3%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 26.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 35.7%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 19.9%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.2 15.2 25.3%
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