GSM8077554

Dataset: gse255685 • Sample: YZ634 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 72.2%ile (≈ Median)
22,388 Genes with score > 0 Group median: 22,378 • 65.2%ile (≈ Median)
0 Median expression score Group median: 0 • 68.6%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

48.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.86
bar=donor   line=cohort median 		2.02 22.4%
FOXO3 Insulin/IGF-1 Signaling 10.17
bar=donor   line=cohort median 		9.99 79.8%
CETP Lipid Metabolism 4.86
bar=donor   line=cohort median 		5.05 28.9%
SIRT6 Sirtuin Family 8.53
bar=donor   line=cohort median 		8.34 81.5%
SIRT1 Sirtuin Family 8.54
bar=donor   line=cohort median 		8.72 24.9%
SIRT3 Sirtuin Family 7.43
bar=donor   line=cohort median 		7.49 38.5%
IGF1R Insulin/IGF-1 Signaling 10.28
bar=donor   line=cohort median 		10.21 56.8%
KLOTHO Anti-aging 2.58
bar=donor   line=cohort median 		2.51 61.1%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 82.3%
IL6 Inflammation 1.02
bar=donor   line=cohort median 		1.16 15.6%
TERT Telomere Maintenance 1.42
bar=donor   line=cohort median 		1.51 27.8%
IRS2 Insulin/IGF-1 Signaling 10.23
bar=donor   line=cohort median 		9.81 73.7%
TP53 Tumor Suppression 8.80
bar=donor   line=cohort median 		8.92 39.3%
SHC1 Signal Transduction 9.28
bar=donor   line=cohort median 		9.35 24.6%
ACE Signal Transduction 4.85
bar=donor   line=cohort median 		4.64 73.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 16.9 0
3 EEF1A1 16.8 0
4 ACTB 16.6 0
5 MT-CO1 16.4 0
6 HLA-C 16.0 0
7 HLA-B 16.0 0
8 FTL 15.9 0
9 MT-RNR1 15.9 0
10 HLA-E 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.0
bar=donor   line=cohort median 		14.2 14.2 37.5%
2 S100A9 15.5
bar=donor   line=cohort median 		15.4 15.5 47.8%
3 IL1B 9.0
bar=donor   line=cohort median 		9.5 9.3 37.1%
4 CXCL8 11.6
bar=donor   line=cohort median 		10.3 11.4 56.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.7
bar=donor   line=cohort median 		6.1 6.1 79.7%
6 FCGR3B 15.1
bar=donor   line=cohort median 		14.7 14.7 76.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.4 14.3 20.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.0
bar=donor   line=cohort median 		10.3 10.4 13.8%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 14.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.6
bar=donor   line=cohort median 		10.9 10.9 98.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 17.0%
12 GNLY 12.2
bar=donor   line=cohort median 		12.0 12.1 59.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 51.4%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 47.8%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 56.1%
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