GSM8077555

Dataset: gse255685 • Sample: YZ638 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 12.7%ile (↓ Low)
22,334 Genes with score > 0 Group median: 22,378 • 6.6%ile (↓ Low)
0 Median expression score Group median: 0 • 10.2%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

46.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.16
bar=donor   line=cohort median 		2.02 71.9%
FOXO3 Insulin/IGF-1 Signaling 9.75
bar=donor   line=cohort median 		9.99 21.0%
CETP Lipid Metabolism 5.34
bar=donor   line=cohort median 		5.05 81.9%
SIRT6 Sirtuin Family 8.48
bar=donor   line=cohort median 		8.34 75.5%
SIRT1 Sirtuin Family 8.69
bar=donor   line=cohort median 		8.72 46.4%
SIRT3 Sirtuin Family 7.52
bar=donor   line=cohort median 		7.49 56.1%
IGF1R Insulin/IGF-1 Signaling 9.84
bar=donor   line=cohort median 		10.21 19.5%
KLOTHO Anti-aging 2.75
bar=donor   line=cohort median 		2.51 82.3%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 15.2%
IL6 Inflammation 1.21
bar=donor   line=cohort median 		1.16 61.8%
TERT Telomere Maintenance 1.35
bar=donor   line=cohort median 		1.51 13.8%
IRS2 Insulin/IGF-1 Signaling 9.24
bar=donor   line=cohort median 		9.81 6.6%
TP53 Tumor Suppression 8.97
bar=donor   line=cohort median 		8.92 58.2%
SHC1 Signal Transduction 9.31
bar=donor   line=cohort median 		9.35 37.1%
ACE Signal Transduction 4.66
bar=donor   line=cohort median 		4.64 51.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.8 0
2 B2M 17.3 0
3 EEF1A1 16.6 0
4 ACTB 16.6 0
5 MT-RNR1 16.2 0
6 MT-CO1 16.2 0
7 HLA-C 16.1 0
8 HLA-B 16.0 0
9 HLA-E 15.9 0
10 TMSB4X 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.8
bar=donor   line=cohort median 		14.2 14.2 86.2%
2 S100A9 15.8
bar=donor   line=cohort median 		15.4 15.5 72.2%
3 IL1B 9.8
bar=donor   line=cohort median 		9.5 9.3 75.4%
4 CXCL8 8.9
bar=donor   line=cohort median 		10.3 11.4 10.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.1 6.1 9.5%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.7 14.7 82.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.1
bar=donor   line=cohort median 		14.4 14.3 28.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 70.8%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 55.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.5
bar=donor   line=cohort median 		10.9 10.9 96.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.5 11.7 55.4%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 66.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 7.7%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.3 15.3 31.7%
18 MT-ND1 15.4
bar=donor   line=cohort median 		15.2 15.2 75.4%
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