GSM8077556

Dataset: gse255685 • Sample: YZ639 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 70.4%ile (≈ Median)
22,356 Genes with score > 0 Group median: 22,378 • 21.5%ile (↓ Low)
0 Median expression score Group median: 0 • 18.1%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

46.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.73
bar=donor   line=cohort median 		2.02 5.6%
FOXO3 Insulin/IGF-1 Signaling 10.23
bar=donor   line=cohort median 		9.99 85.5%
CETP Lipid Metabolism 5.35
bar=donor   line=cohort median 		5.05 83.0%
SIRT6 Sirtuin Family 8.11
bar=donor   line=cohort median 		8.34 5.6%
SIRT1 Sirtuin Family 8.70
bar=donor   line=cohort median 		8.72 48.2%
SIRT3 Sirtuin Family 7.35
bar=donor   line=cohort median 		7.49 24.6%
IGF1R Insulin/IGF-1 Signaling 10.88
bar=donor   line=cohort median 		10.21 99.5%
KLOTHO Anti-aging 2.20
bar=donor   line=cohort median 		2.51 9.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 69.4%
IL6 Inflammation 1.01
bar=donor   line=cohort median 		1.16 13.8%
TERT Telomere Maintenance 1.72
bar=donor   line=cohort median 		1.51 85.1%
IRS2 Insulin/IGF-1 Signaling 10.32
bar=donor   line=cohort median 		9.81 79.4%
TP53 Tumor Suppression 8.74
bar=donor   line=cohort median 		8.92 31.7%
SHC1 Signal Transduction 9.24
bar=donor   line=cohort median 		9.35 13.4%
ACE Signal Transduction 4.61
bar=donor   line=cohort median 		4.64 48.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.9 0
2 B2M 17.2 0
3 EEF1A1 16.6 0
4 ACTB 16.5 0
5 S100A9 16.3 0
6 MT-CO1 16.3 0
7 MT-RNR1 16.2 0
8 HLA-C 16.0 0
9 HLA-E 15.9 0
10 TXNIP 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.5
bar=donor   line=cohort median 		14.2 14.2 98.0%
2 S100A9 16.3
bar=donor   line=cohort median 		15.4 15.5 91.6%
3 IL1B 10.5
bar=donor   line=cohort median 		9.5 9.3 97.7%
4 CXCL8 9.7
bar=donor   line=cohort median 		10.3 11.4 22.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.1 6.1 41.8%
6 FCGR3B 15.3
bar=donor   line=cohort median 		14.7 14.7 90.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.4 14.3 57.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.3 10.4 20.3%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 15.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 68.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 26.7%
12 GNLY 12.2
bar=donor   line=cohort median 		12.0 12.1 53.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 20.6%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 38.5%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 61.8%
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