GSM8077557

Dataset: gse255685 • Sample: YZ642 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 84.4%ile (↑ High)
22,380 Genes with score > 0 Group median: 22,378 • 53.8%ile (≈ Median)
0 Median expression score Group median: 0 • 33.2%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

44.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.14
bar=donor   line=cohort median 		2.02 68.6%
FOXO3 Insulin/IGF-1 Signaling 9.98
bar=donor   line=cohort median 		9.99 47.5%
CETP Lipid Metabolism 5.25
bar=donor   line=cohort median 		5.05 76.5%
SIRT6 Sirtuin Family 8.16
bar=donor   line=cohort median 		8.34 12.7%
SIRT1 Sirtuin Family 8.79
bar=donor   line=cohort median 		8.72 65.1%
SIRT3 Sirtuin Family 7.47
bar=donor   line=cohort median 		7.49 46.8%
IGF1R Insulin/IGF-1 Signaling 10.13
bar=donor   line=cohort median 		10.21 42.5%
KLOTHO Anti-aging 2.50
bar=donor   line=cohort median 		2.51 48.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 34.6%
IL6 Inflammation 0.99
bar=donor   line=cohort median 		1.16 5.6%
TERT Telomere Maintenance 2.26
bar=donor   line=cohort median 		1.51 99.8%
IRS2 Insulin/IGF-1 Signaling 9.30
bar=donor   line=cohort median 		9.81 8.1%
TP53 Tumor Suppression 9.01
bar=donor   line=cohort median 		8.92 65.1%
SHC1 Signal Transduction 9.27
bar=donor   line=cohort median 		9.35 21.7%
ACE Signal Transduction 4.39
bar=donor   line=cohort median 		4.64 25.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 16.9 0
3 EEF1A1 16.6 0
4 ACTB 16.5 0
5 MT-CO1 16.2 0
6 HLA-B 15.7 0
7 MT-RNR1 15.7 0
8 HLA-E 15.6 0
9 IGHM 15.6 0
10 TMSB4X 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		14.2 14.2 55.4%
2 S100A9 15.4
bar=donor   line=cohort median 		15.4 15.5 41.4%
3 IL1B 9.4
bar=donor   line=cohort median 		9.5 9.3 56.1%
4 CXCL8 8.9
bar=donor   line=cohort median 		10.3 11.4 9.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.1 6.1 24.9%
6 FCGR3B 14.7
bar=donor   line=cohort median 		14.7 14.7 56.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 69.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.0
bar=donor   line=cohort median 		10.3 10.4 12.0%
9 CD3E 11.5
bar=donor   line=cohort median 		11.9 12.0 1.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.5
bar=donor   line=cohort median 		10.9 10.9 14.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.2
bar=donor   line=cohort median 		11.5 11.7 10.6%
12 GNLY 11.5
bar=donor   line=cohort median 		12.0 12.1 9.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 8.4%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.3 15.3 5.9%
18 MT-ND1 14.8
bar=donor   line=cohort median 		15.2 15.2 8.4%
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