GSM8077558

Dataset: gse255685 • Sample: YZ645 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 50.4%ile (≈ Median)
22,369 Genes with score > 0 Group median: 22,378 • 37.1%ile (≈ Median)
0 Median expression score Group median: 0 • 26.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

48.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.96
bar=donor   line=cohort median 		2.02 41.0%
FOXO3 Insulin/IGF-1 Signaling 10.19
bar=donor   line=cohort median 		9.99 83.0%
CETP Lipid Metabolism 5.05
bar=donor   line=cohort median 		5.05 50.4%
SIRT6 Sirtuin Family 8.27
bar=donor   line=cohort median 		8.34 32.4%
SIRT1 Sirtuin Family 9.05
bar=donor   line=cohort median 		8.72 97.0%
SIRT3 Sirtuin Family 7.38
bar=donor   line=cohort median 		7.49 31.0%
IGF1R Insulin/IGF-1 Signaling 10.79
bar=donor   line=cohort median 		10.21 98.0%
KLOTHO Anti-aging 2.63
bar=donor   line=cohort median 		2.51 68.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 43.9%
IL6 Inflammation 1.17
bar=donor   line=cohort median 		1.16 53.6%
TERT Telomere Maintenance 1.28
bar=donor   line=cohort median 		1.51 3.1%
IRS2 Insulin/IGF-1 Signaling 9.66
bar=donor   line=cohort median 		9.81 33.9%
TP53 Tumor Suppression 8.87
bar=donor   line=cohort median 		8.92 46.8%
SHC1 Signal Transduction 9.27
bar=donor   line=cohort median 		9.35 22.0%
ACE Signal Transduction 4.32
bar=donor   line=cohort median 		4.64 17.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.5 0
2 B2M 17.0 0
3 EEF1A1 16.6 0
4 ACTB 16.5 0
5 MT-CO1 16.2 0
6 HLA-C 16.1 0
7 MT-RNR1 15.9 0
8 HLA-B 15.8 0
9 S100A9 15.7 0
10 HLA-E 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.6
bar=donor   line=cohort median 		14.2 14.2 76.5%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 63.6%
3 IL1B 9.8
bar=donor   line=cohort median 		9.5 9.3 78.7%
4 CXCL8 9.4
bar=donor   line=cohort median 		10.3 11.4 17.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.9
bar=donor   line=cohort median 		6.1 6.1 37.8%
6 FCGR3B 14.9
bar=donor   line=cohort median 		14.7 14.7 67.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.4 14.3 24.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.3 10.4 19.2%
9 CD3E 11.7
bar=donor   line=cohort median 		11.9 12.0 9.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.2
bar=donor   line=cohort median 		10.9 10.9 81.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 14.2%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 37.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 10.2%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 18.8%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 35.7%
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