GSM8077559

Dataset: gse255685 • Sample: YZ646 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 15.6%ile (↓ Low)
22,340 Genes with score > 0 Group median: 22,378 • 9.5%ile (↓ Low)
0 Median expression score Group median: 0 • 5.6%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

45.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.09
bar=donor   line=cohort median 		2.02 61.5%
FOXO3 Insulin/IGF-1 Signaling 9.88
bar=donor   line=cohort median 		9.99 33.5%
CETP Lipid Metabolism 5.21
bar=donor   line=cohort median 		5.05 72.2%
SIRT6 Sirtuin Family 8.14
bar=donor   line=cohort median 		8.34 9.9%
SIRT1 Sirtuin Family 8.81
bar=donor   line=cohort median 		8.72 69.0%
SIRT3 Sirtuin Family 7.53
bar=donor   line=cohort median 		7.49 57.9%
IGF1R Insulin/IGF-1 Signaling 10.24
bar=donor   line=cohort median 		10.21 52.9%
KLOTHO Anti-aging 2.07
bar=donor   line=cohort median 		2.51 1.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 36.7%
IL6 Inflammation 1.16
bar=donor   line=cohort median 		1.16 51.1%
TERT Telomere Maintenance 1.37
bar=donor   line=cohort median 		1.51 17.0%
IRS2 Insulin/IGF-1 Signaling 9.35
bar=donor   line=cohort median 		9.81 12.7%
TP53 Tumor Suppression 8.98
bar=donor   line=cohort median 		8.92 60.8%
SHC1 Signal Transduction 9.35
bar=donor   line=cohort median 		9.35 50.0%
ACE Signal Transduction 5.41
bar=donor   line=cohort median 		4.64 97.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.8 0
2 B2M 17.1 0
3 EEF1A1 16.6 0
4 ACTB 16.5 0
5 MT-CO1 16.3 0
6 MT-RNR1 16.3 0
7 HLA-C 16.2 0
8 HLA-B 15.9 0
9 HLA-E 15.8 0
10 S100A9 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.7
bar=donor   line=cohort median 		14.2 14.2 83.3%
2 S100A9 15.8
bar=donor   line=cohort median 		15.4 15.5 71.5%
3 IL1B 9.8
bar=donor   line=cohort median 		9.5 9.3 77.2%
4 CXCL8 9.5
bar=donor   line=cohort median 		10.3 11.4 18.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.1 6.1 7.3%
6 FCGR3B 15.0
bar=donor   line=cohort median 		14.7 14.7 73.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 42.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 49.6%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 46.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		10.9 10.9 90.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.5 11.7 47.8%
12 GNLY 12.5
bar=donor   line=cohort median 		12.0 12.1 76.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 16.3%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 19.2%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 29.9%
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