GSM8077561

Dataset: gse255685 • Sample: YZ648 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 11.3%ile (↓ Low)
22,390 Genes with score > 0 Group median: 22,375 • 67.7%ile (≈ Median)
0 Median expression score Group median: 0 • 50.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

37.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.03
bar=donor   line=cohort median 		2.02 50.4%
FOXO3 Insulin/IGF-1 Signaling 9.70
bar=donor   line=cohort median 		9.99 15.2%
CETP Lipid Metabolism 4.90
bar=donor   line=cohort median 		5.05 33.5%
SIRT6 Sirtuin Family 8.16
bar=donor   line=cohort median 		8.34 12.0%
SIRT1 Sirtuin Family 8.56
bar=donor   line=cohort median 		8.72 27.4%
SIRT3 Sirtuin Family 7.59
bar=donor   line=cohort median 		7.49 67.2%
IGF1R Insulin/IGF-1 Signaling 9.88
bar=donor   line=cohort median 		10.21 23.1%
KLOTHO Anti-aging 2.52
bar=donor   line=cohort median 		2.51 51.1%
APOC3 Lipid Metabolism -2.12
bar=donor   line=cohort median 		-2.11 1.6%
IL6 Inflammation 1.17
bar=donor   line=cohort median 		1.16 51.8%
TERT Telomere Maintenance 1.87
bar=donor   line=cohort median 		1.51 94.8%
IRS2 Insulin/IGF-1 Signaling 9.46
bar=donor   line=cohort median 		9.81 19.5%
TP53 Tumor Suppression 8.96
bar=donor   line=cohort median 		8.92 56.8%
SHC1 Signal Transduction 9.27
bar=donor   line=cohort median 		9.35 22.4%
ACE Signal Transduction 4.44
bar=donor   line=cohort median 		4.64 30.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 EEF1A1 17.0 0
3 B2M 16.7 0
4 MT-CO1 16.6 0
5 ACTB 16.3 0
6 MT-ND4 15.8 0
7 MT-RNR1 15.7 0
8 HLA-B 15.6 0
9 HLA-E 15.5 0
10 MT-CO3 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.3
bar=donor   line=cohort median 		13.8 14.2 10.9%
2 S100A9 14.8
bar=donor   line=cohort median 		15.3 15.5 8.4%
3 IL1B 8.1
bar=donor   line=cohort median 		9.5 9.3 5.2%
4 CXCL8 11.2
bar=donor   line=cohort median 		10.6 11.4 45.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.3
bar=donor   line=cohort median 		6.0 6.1 1.6%
6 FCGR3B 14.3
bar=donor   line=cohort median 		14.6 14.7 20.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.6
bar=donor   line=cohort median 		14.3 14.3 3.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.7
bar=donor   line=cohort median 		10.2 10.4 84.1%
9 CD3E 12.3
bar=donor   line=cohort median 		11.9 12.0 88.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.5
bar=donor   line=cohort median 		11.0 10.9 97.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.6
bar=donor   line=cohort median 		11.7 11.7 46.4%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 36.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 88.4%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.2 15.3 72.9%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.0 15.2 34.6%
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