GSM8077566

Dataset: gse255685 • Sample: YZ667 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 76.9%ile (↑ High)
22,417 Genes with score > 0 Group median: 22,375 • 88.0%ile (↑ High)
0 Median expression score Group median: 0 • 78.7%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

57.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.89
bar=donor   line=cohort median 		2.02 28.9%
FOXO3 Insulin/IGF-1 Signaling 10.49
bar=donor   line=cohort median 		9.99 96.6%
CETP Lipid Metabolism 5.06
bar=donor   line=cohort median 		5.05 51.8%
SIRT6 Sirtuin Family 8.17
bar=donor   line=cohort median 		8.34 14.9%
SIRT1 Sirtuin Family 8.64
bar=donor   line=cohort median 		8.72 40.7%
SIRT3 Sirtuin Family 7.58
bar=donor   line=cohort median 		7.49 65.8%
IGF1R Insulin/IGF-1 Signaling 10.33
bar=donor   line=cohort median 		10.21 63.3%
KLOTHO Anti-aging 2.65
bar=donor   line=cohort median 		2.51 69.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 52.2%
IL6 Inflammation 1.18
bar=donor   line=cohort median 		1.16 55.7%
TERT Telomere Maintenance 1.61
bar=donor   line=cohort median 		1.51 72.2%
IRS2 Insulin/IGF-1 Signaling 10.83
bar=donor   line=cohort median 		9.81 94.1%
TP53 Tumor Suppression 8.59
bar=donor   line=cohort median 		8.92 15.6%
SHC1 Signal Transduction 9.42
bar=donor   line=cohort median 		9.35 72.9%
ACE Signal Transduction 4.86
bar=donor   line=cohort median 		4.64 74.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 EEF1A1 17.1 0
3 B2M 17.0 0
4 MT-CO1 16.6 0
5 ACTB 16.5 0
6 HLA-C 16.2 0
7 FTL 15.9 0
8 MT-RNR1 15.9 0
9 TXNIP 15.8 0
10 HLA-E 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.6
bar=donor   line=cohort median 		13.8 14.2 19.5%
2 S100A9 15.3
bar=donor   line=cohort median 		15.3 15.5 28.9%
3 IL1B 8.2
bar=donor   line=cohort median 		9.5 9.3 7.3%
4 CXCL8 11.5
bar=donor   line=cohort median 		10.6 11.4 54.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.0 6.1 12.0%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.6 14.7 29.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.3 14.3 79.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.2 10.4 32.1%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 57.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		11.0 10.9 40.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.7 11.7 32.4%
12 GNLY 12.0
bar=donor   line=cohort median 		12.0 12.1 39.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 86.9%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.2 15.3 65.4%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.0 15.2 50.0%
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