GSM8077568

Dataset: gse255685 • Sample: YZ671 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 27.4%ile (≈ Median)
22,353 Genes with score > 0 Group median: 22,378 • 17.6%ile (↓ Low)
0 Median expression score Group median: 0 • 10.9%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

44.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.99
bar=donor   line=cohort median 		2.02 45.7%
FOXO3 Insulin/IGF-1 Signaling 9.78
bar=donor   line=cohort median 		9.99 22.8%
CETP Lipid Metabolism 5.04
bar=donor   line=cohort median 		5.05 49.3%
SIRT6 Sirtuin Family 8.39
bar=donor   line=cohort median 		8.34 61.8%
SIRT1 Sirtuin Family 8.90
bar=donor   line=cohort median 		8.72 83.7%
SIRT3 Sirtuin Family 7.47
bar=donor   line=cohort median 		7.49 46.1%
IGF1R Insulin/IGF-1 Signaling 9.84
bar=donor   line=cohort median 		10.21 18.8%
KLOTHO Anti-aging 2.36
bar=donor   line=cohort median 		2.51 26.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 63.3%
IL6 Inflammation 1.28
bar=donor   line=cohort median 		1.16 71.9%
TERT Telomere Maintenance 1.56
bar=donor   line=cohort median 		1.51 60.8%
IRS2 Insulin/IGF-1 Signaling 9.72
bar=donor   line=cohort median 		9.81 39.6%
TP53 Tumor Suppression 8.93
bar=donor   line=cohort median 		8.92 52.5%
SHC1 Signal Transduction 9.12
bar=donor   line=cohort median 		9.35 3.8%
ACE Signal Transduction 4.37
bar=donor   line=cohort median 		4.64 22.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.8 0
2 B2M 17.4 0
3 EEF1A1 16.8 0
4 ACTB 16.7 0
5 MT-CO1 16.4 0
6 MT-RNR1 16.3 0
7 S100A9 16.3 0
8 HLA-B 16.3 0
9 TMSB4X 16.1 0
10 HLA-C 16.1 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 15.3
bar=donor   line=cohort median 		14.2 14.2 97.0%
2 S100A9 16.3
bar=donor   line=cohort median 		15.4 15.5 90.5%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 79.7%
4 CXCL8 10.7
bar=donor   line=cohort median 		10.3 11.4 36.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.5
bar=donor   line=cohort median 		6.1 6.1 93.4%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.7 14.7 86.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 70.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 71.5%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 47.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 52.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 23.1%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 24.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 35.3%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 62.9%
18 MT-ND1 15.5
bar=donor   line=cohort median 		15.2 15.2 82.6%
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