GSM8077569

Dataset: gse255685 • Sample: YZ673 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 39.6%ile (≈ Median)
22,377 Genes with score > 0 Group median: 22,375 • 48.2%ile (≈ Median)
0 Median expression score Group median: 0 • 45.0%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

47.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.87
bar=donor   line=cohort median 		2.02 25.3%
FOXO3 Insulin/IGF-1 Signaling 9.83
bar=donor   line=cohort median 		9.99 27.1%
CETP Lipid Metabolism 5.12
bar=donor   line=cohort median 		5.05 60.8%
SIRT6 Sirtuin Family 8.22
bar=donor   line=cohort median 		8.34 22.8%
SIRT1 Sirtuin Family 8.86
bar=donor   line=cohort median 		8.72 75.8%
SIRT3 Sirtuin Family 7.53
bar=donor   line=cohort median 		7.49 57.2%
IGF1R Insulin/IGF-1 Signaling 10.13
bar=donor   line=cohort median 		10.21 43.2%
KLOTHO Anti-aging 2.56
bar=donor   line=cohort median 		2.51 57.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 35.3%
IL6 Inflammation 1.31
bar=donor   line=cohort median 		1.16 78.0%
TERT Telomere Maintenance 1.83
bar=donor   line=cohort median 		1.51 92.3%
IRS2 Insulin/IGF-1 Signaling 9.14
bar=donor   line=cohort median 		9.81 3.1%
TP53 Tumor Suppression 9.01
bar=donor   line=cohort median 		8.92 66.5%
SHC1 Signal Transduction 9.29
bar=donor   line=cohort median 		9.35 27.1%
ACE Signal Transduction 4.60
bar=donor   line=cohort median 		4.64 47.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 EEF1A1 16.9 0
3 B2M 16.7 0
4 MT-CO1 16.4 0
5 ACTB 16.3 0
6 MT-RNR1 15.9 0
7 HLA-C 15.8 0
8 MT-ND4 15.6 0
9 HLA-E 15.4 0
10 TXNIP 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.2
bar=donor   line=cohort median 		13.8 14.2 10.6%
2 S100A9 14.7
bar=donor   line=cohort median 		15.3 15.5 5.2%
3 IL1B 9.1
bar=donor   line=cohort median 		9.5 9.3 40.3%
4 CXCL8 10.3
bar=donor   line=cohort median 		10.6 11.4 30.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.0 6.1 8.8%
6 FCGR3B 14.0
bar=donor   line=cohort median 		14.6 14.7 10.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.3
bar=donor   line=cohort median 		14.3 14.3 44.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.2 10.4 67.2%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 77.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		11.0 10.9 74.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.7 11.7 37.5%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 69.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 49.3%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.2 15.3 44.3%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.0 15.2 16.3%
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