GSM8077571

Dataset: gse255685 • Sample: YZ679 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 75.1%ile (↑ High)
22,386 Genes with score > 0 Group median: 22,378 • 62.9%ile (≈ Median)
0 Median expression score Group median: 0 • 82.3%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

39.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.94
bar=donor   line=cohort median 		2.02 37.5%
FOXO3 Insulin/IGF-1 Signaling 9.81
bar=donor   line=cohort median 		9.99 25.6%
CETP Lipid Metabolism 5.08
bar=donor   line=cohort median 		5.05 55.4%
SIRT6 Sirtuin Family 8.21
bar=donor   line=cohort median 		8.34 21.3%
SIRT1 Sirtuin Family 8.83
bar=donor   line=cohort median 		8.72 72.6%
SIRT3 Sirtuin Family 7.61
bar=donor   line=cohort median 		7.49 71.2%
IGF1R Insulin/IGF-1 Signaling 10.27
bar=donor   line=cohort median 		10.21 56.1%
KLOTHO Anti-aging 2.70
bar=donor   line=cohort median 		2.51 76.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 31.0%
IL6 Inflammation 1.08
bar=donor   line=cohort median 		1.16 26.3%
TERT Telomere Maintenance 1.28
bar=donor   line=cohort median 		1.51 2.0%
IRS2 Insulin/IGF-1 Signaling 9.47
bar=donor   line=cohort median 		9.81 20.6%
TP53 Tumor Suppression 8.96
bar=donor   line=cohort median 		8.92 55.4%
SHC1 Signal Transduction 9.07
bar=donor   line=cohort median 		9.35 2.0%
ACE Signal Transduction 4.58
bar=donor   line=cohort median 		4.64 44.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 B2M 16.8 0
3 EEF1A1 16.7 0
4 ACTB 16.3 0
5 MT-CO1 16.1 0
6 HLA-C 15.8 0
7 MT-RNR1 15.7 0
8 MT-ND4 15.6 0
9 TMSB4X 15.6 0
10 HLA-E 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.1
bar=donor   line=cohort median 		14.2 14.2 46.8%
2 S100A9 15.2
bar=donor   line=cohort median 		15.4 15.5 28.5%
3 IL1B 9.4
bar=donor   line=cohort median 		9.5 9.3 53.9%
4 CXCL8 10.6
bar=donor   line=cohort median 		10.3 11.4 33.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.7
bar=donor   line=cohort median 		6.1 6.1 81.2%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 34.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.4 14.3 22.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 54.3%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 55.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		10.9 10.9 85.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.2
bar=donor   line=cohort median 		11.5 11.7 11.6%
12 GNLY 11.7
bar=donor   line=cohort median 		12.0 12.1 18.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.1
bar=donor   line=cohort median 		16.4 16.4 2.3%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.3 15.3 28.1%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.2 15.2 13.1%
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