GSM8077572

Dataset: gse255685 • Sample: YZ680 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 8.8%ile (↓ Low)
22,329 Genes with score > 0 Group median: 22,378 • 4.8%ile (↓ Low)
0 Median expression score Group median: 0 • 4.5%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

37.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.71
bar=donor   line=cohort median 		2.02 2.3%
FOXO3 Insulin/IGF-1 Signaling 9.86
bar=donor   line=cohort median 		9.99 30.7%
CETP Lipid Metabolism 4.93
bar=donor   line=cohort median 		5.05 36.0%
SIRT6 Sirtuin Family 8.35
bar=donor   line=cohort median 		8.34 54.3%
SIRT1 Sirtuin Family 8.70
bar=donor   line=cohort median 		8.72 48.9%
SIRT3 Sirtuin Family 7.36
bar=donor   line=cohort median 		7.49 28.1%
IGF1R Insulin/IGF-1 Signaling 10.33
bar=donor   line=cohort median 		10.21 61.5%
KLOTHO Anti-aging 2.60
bar=donor   line=cohort median 		2.51 64.3%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 54.3%
IL6 Inflammation 1.00
bar=donor   line=cohort median 		1.16 9.5%
TERT Telomere Maintenance 1.38
bar=donor   line=cohort median 		1.51 21.3%
IRS2 Insulin/IGF-1 Signaling 9.32
bar=donor   line=cohort median 		9.81 9.9%
TP53 Tumor Suppression 9.13
bar=donor   line=cohort median 		8.92 84.8%
SHC1 Signal Transduction 9.32
bar=donor   line=cohort median 		9.35 40.7%
ACE Signal Transduction 4.28
bar=donor   line=cohort median 		4.64 15.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 17.0 0
3 EEF1A1 16.9 0
4 ACTB 16.8 0
5 MT-CO1 16.5 0
6 MT-RNR1 16.3 0
7 HLA-C 16.1 0
8 HLA-B 16.0 0
9 HLA-E 15.8 0
10 FTL 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		14.2 14.2 48.2%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 60.0%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 62.9%
4 CXCL8 9.7
bar=donor   line=cohort median 		10.3 11.4 24.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 8.2
bar=donor   line=cohort median 		6.1 6.1 98.0%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.7 14.7 39.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 74.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 73.3%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 63.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 56.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.9
bar=donor   line=cohort median 		11.5 11.7 66.5%
12 GNLY 12.8
bar=donor   line=cohort median 		12.0 12.1 85.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 57.2%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 60.8%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 47.1%
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