GSM8077573

Dataset: gse255685 • Sample: YZ686 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 41.0%ile (≈ Median)
22,376 Genes with score > 0 Group median: 22,375 • 46.8%ile (≈ Median)
0 Median expression score Group median: 0 • 32.8%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.00
bar=donor   line=cohort median 		2.02 46.8%
FOXO3 Insulin/IGF-1 Signaling 10.21
bar=donor   line=cohort median 		9.99 84.8%
CETP Lipid Metabolism 4.83
bar=donor   line=cohort median 		5.05 23.5%
SIRT6 Sirtuin Family 8.48
bar=donor   line=cohort median 		8.34 73.3%
SIRT1 Sirtuin Family 8.58
bar=donor   line=cohort median 		8.72 30.7%
SIRT3 Sirtuin Family 7.64
bar=donor   line=cohort median 		7.49 76.9%
IGF1R Insulin/IGF-1 Signaling 10.12
bar=donor   line=cohort median 		10.21 42.1%
KLOTHO Anti-aging 2.44
bar=donor   line=cohort median 		2.51 41.0%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 66.1%
IL6 Inflammation 1.28
bar=donor   line=cohort median 		1.16 73.3%
TERT Telomere Maintenance 1.29
bar=donor   line=cohort median 		1.51 6.3%
IRS2 Insulin/IGF-1 Signaling 10.40
bar=donor   line=cohort median 		9.81 80.8%
TP53 Tumor Suppression 8.65
bar=donor   line=cohort median 		8.92 20.3%
SHC1 Signal Transduction 9.42
bar=donor   line=cohort median 		9.35 72.2%
ACE Signal Transduction 4.77
bar=donor   line=cohort median 		4.64 63.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 17.1 0
3 EEF1A1 16.8 0
4 ACTB 16.8 0
5 MT-CO1 16.7 0
6 HLA-B 16.1 0
7 FTL 16.0 0
8 MT-RNR1 16.0 0
9 HLA-C 16.0 0
10 HLA-E 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.3
bar=donor   line=cohort median 		13.8 14.2 57.5%
2 S100A9 15.8
bar=donor   line=cohort median 		15.3 15.5 68.6%
3 IL1B 8.7
bar=donor   line=cohort median 		9.5 9.3 21.7%
4 CXCL8 11.5
bar=donor   line=cohort median 		10.6 11.4 52.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.8
bar=donor   line=cohort median 		6.0 6.1 82.6%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.6 14.7 40.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.4
bar=donor   line=cohort median 		14.3 14.3 53.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.2 10.4 23.8%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 17.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		11.0 10.9 40.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.7 11.7 58.2%
12 GNLY 12.1
bar=donor   line=cohort median 		12.0 12.1 48.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.7
bar=donor   line=cohort median 		16.4 16.4 89.8%
17 MT-CO2 15.6
bar=donor   line=cohort median 		15.2 15.3 79.0%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.0 15.2 62.5%
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