GSM8077575

Dataset: gse255685 • Sample: YZ688 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 18.5%ile (↓ Low)
22,355 Genes with score > 0 Group median: 22,378 • 19.7%ile (↓ Low)
0 Median expression score Group median: 0 • 29.2%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.06
bar=donor   line=cohort median 		2.02 56.8%
FOXO3 Insulin/IGF-1 Signaling 9.88
bar=donor   line=cohort median 		9.99 34.2%
CETP Lipid Metabolism 5.74
bar=donor   line=cohort median 		5.05 97.0%
SIRT6 Sirtuin Family 8.36
bar=donor   line=cohort median 		8.34 58.6%
SIRT1 Sirtuin Family 8.88
bar=donor   line=cohort median 		8.72 79.8%
SIRT3 Sirtuin Family 7.37
bar=donor   line=cohort median 		7.49 29.9%
IGF1R Insulin/IGF-1 Signaling 10.37
bar=donor   line=cohort median 		10.21 69.7%
KLOTHO Anti-aging 2.42
bar=donor   line=cohort median 		2.51 38.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 60.0%
IL6 Inflammation 1.10
bar=donor   line=cohort median 		1.16 34.2%
TERT Telomere Maintenance 1.47
bar=donor   line=cohort median 		1.51 42.1%
IRS2 Insulin/IGF-1 Signaling 9.58
bar=donor   line=cohort median 		9.81 27.4%
TP53 Tumor Suppression 8.99
bar=donor   line=cohort median 		8.92 61.5%
SHC1 Signal Transduction 9.22
bar=donor   line=cohort median 		9.35 9.5%
ACE Signal Transduction 4.65
bar=donor   line=cohort median 		4.64 50.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 18.0 0
2 B2M 17.2 0
3 ACTB 16.7 0
4 EEF1A1 16.6 0
5 MT-RNR1 16.5 0
6 MT-CO1 16.5 0
7 HLA-B 16.1 0
8 HLA-C 16.1 0
9 HLA-E 16.0 0
10 MT-ND4 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.8
bar=donor   line=cohort median 		14.2 14.2 85.1%
2 S100A9 15.9
bar=donor   line=cohort median 		15.4 15.5 74.7%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 59.0%
4 CXCL8 9.2
bar=donor   line=cohort median 		10.3 11.4 14.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.3
bar=donor   line=cohort median 		6.1 6.1 64.3%
6 FCGR3B 15.1
bar=donor   line=cohort median 		14.7 14.7 81.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 43.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.3 10.4 73.7%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 71.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 45.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.9
bar=donor   line=cohort median 		11.5 11.7 63.3%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 67.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 59.0%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.3 15.3 74.4%
18 MT-ND1 15.7
bar=donor   line=cohort median 		15.2 15.2 93.7%
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