GSM8077577

Dataset: gse255685 • Sample: YZ791 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 78.7%ile (↑ High)
22,411 Genes with score > 0 Group median: 22,375 • 85.5%ile (↑ High)
0 Median expression score Group median: 0 • 77.2%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.77
bar=donor   line=cohort median 		2.02 9.1%
FOXO3 Insulin/IGF-1 Signaling 9.91
bar=donor   line=cohort median 		9.99 38.2%
CETP Lipid Metabolism 4.82
bar=donor   line=cohort median 		5.05 22.4%
SIRT6 Sirtuin Family 8.26
bar=donor   line=cohort median 		8.34 29.9%
SIRT1 Sirtuin Family 8.58
bar=donor   line=cohort median 		8.72 31.0%
SIRT3 Sirtuin Family 7.74
bar=donor   line=cohort median 		7.49 90.5%
IGF1R Insulin/IGF-1 Signaling 10.12
bar=donor   line=cohort median 		10.21 41.4%
KLOTHO Anti-aging 2.46
bar=donor   line=cohort median 		2.51 45.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 18.5%
IL6 Inflammation 1.41
bar=donor   line=cohort median 		1.16 86.2%
TERT Telomere Maintenance 1.68
bar=donor   line=cohort median 		1.51 82.3%
IRS2 Insulin/IGF-1 Signaling 10.24
bar=donor   line=cohort median 		9.81 74.7%
TP53 Tumor Suppression 8.77
bar=donor   line=cohort median 		8.92 35.0%
SHC1 Signal Transduction 9.37
bar=donor   line=cohort median 		9.35 58.2%
ACE Signal Transduction 5.27
bar=donor   line=cohort median 		4.64 95.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 17.0 0
3 EEF1A1 16.7 0
4 MT-CO1 16.7 0
5 ACTB 16.6 0
6 MT-RNR1 16.1 0
7 HLA-B 16.0 0
8 MT-ND4 16.0 0
9 S100A9 15.8 0
10 HLA-C 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.6
bar=donor   line=cohort median 		13.8 14.2 78.7%
2 S100A9 15.8
bar=donor   line=cohort median 		15.3 15.5 70.1%
3 IL1B 9.0
bar=donor   line=cohort median 		9.5 9.3 37.5%
4 CXCL8 11.3
bar=donor   line=cohort median 		10.6 11.4 47.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.0 6.1 22.8%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.6 14.7 30.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.3 14.3 72.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.2 10.4 61.8%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 27.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		11.0 10.9 34.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.7 11.7 50.0%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 65.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.7
bar=donor   line=cohort median 		16.4 16.4 91.6%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.2 15.3 71.5%
18 MT-ND1 15.4
bar=donor   line=cohort median 		15.0 15.2 75.8%
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