GSM8077578

Dataset: gse255685 • Sample: YZ792 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 10.6%ile (↓ Low)
22,335 Genes with score > 0 Group median: 22,378 • 7.3%ile (↓ Low)
0 Median expression score Group median: 0 • 5.2%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

57.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.16
bar=donor   line=cohort median 		2.02 72.9%
FOXO3 Insulin/IGF-1 Signaling 10.04
bar=donor   line=cohort median 		9.99 56.8%
CETP Lipid Metabolism 5.52
bar=donor   line=cohort median 		5.05 91.6%
SIRT6 Sirtuin Family 8.23
bar=donor   line=cohort median 		8.34 26.3%
SIRT1 Sirtuin Family 8.90
bar=donor   line=cohort median 		8.72 83.0%
SIRT3 Sirtuin Family 6.96
bar=donor   line=cohort median 		7.49 0.9%
IGF1R Insulin/IGF-1 Signaling 10.42
bar=donor   line=cohort median 		10.21 72.6%
KLOTHO Anti-aging 2.39
bar=donor   line=cohort median 		2.51 32.8%
APOC3 Lipid Metabolism -2.01
bar=donor   line=cohort median 		-2.11 98.8%
IL6 Inflammation 1.09
bar=donor   line=cohort median 		1.16 29.9%
TERT Telomere Maintenance 1.53
bar=donor   line=cohort median 		1.51 53.9%
IRS2 Insulin/IGF-1 Signaling 9.87
bar=donor   line=cohort median 		9.81 54.7%
TP53 Tumor Suppression 9.12
bar=donor   line=cohort median 		8.92 83.3%
SHC1 Signal Transduction 9.45
bar=donor   line=cohort median 		9.35 77.6%
ACE Signal Transduction 4.43
bar=donor   line=cohort median 		4.64 28.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 17.1 0
3 EEF1A1 16.8 0
4 ACTB 16.7 0
5 MT-CO1 16.3 0
6 HLA-B 16.1 0
7 MT-RNR1 16.1 0
8 HLA-C 16.0 0
9 HLA-E 15.9 0
10 FTL 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		14.2 14.2 56.1%
2 S100A9 15.6
bar=donor   line=cohort median 		15.4 15.5 58.2%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 64.3%
4 CXCL8 10.7
bar=donor   line=cohort median 		10.3 11.4 37.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.2
bar=donor   line=cohort median 		6.1 6.1 90.1%
6 FCGR3B 15.5
bar=donor   line=cohort median 		14.7 14.7 96.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.0
bar=donor   line=cohort median 		14.4 14.3 95.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 39.2%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 34.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.7
bar=donor   line=cohort median 		10.9 10.9 27.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 15.2%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 22.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 15.2%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.3 15.3 29.9%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 26.3%
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