GSM8077581

Dataset: gse255685 • Sample: YZ796 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 4.5%ile (↓ Low)
22,324 Genes with score > 0 Group median: 22,375 • 2.0%ile (↓ Low)
0 Median expression score Group median: 0 • 1.3%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

45.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.77
bar=donor   line=cohort median 		2.02 9.5%
FOXO3 Insulin/IGF-1 Signaling 10.03
bar=donor   line=cohort median 		9.99 54.7%
CETP Lipid Metabolism 4.92
bar=donor   line=cohort median 		5.05 35.3%
SIRT6 Sirtuin Family 8.36
bar=donor   line=cohort median 		8.34 56.1%
SIRT1 Sirtuin Family 8.91
bar=donor   line=cohort median 		8.72 86.2%
SIRT3 Sirtuin Family 7.26
bar=donor   line=cohort median 		7.49 12.0%
IGF1R Insulin/IGF-1 Signaling 10.78
bar=donor   line=cohort median 		10.21 97.7%
KLOTHO Anti-aging 2.67
bar=donor   line=cohort median 		2.51 71.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 21.3%
IL6 Inflammation 1.15
bar=donor   line=cohort median 		1.16 47.1%
TERT Telomere Maintenance 1.27
bar=donor   line=cohort median 		1.51 1.3%
IRS2 Insulin/IGF-1 Signaling 9.72
bar=donor   line=cohort median 		9.81 40.0%
TP53 Tumor Suppression 9.13
bar=donor   line=cohort median 		8.92 84.1%
SHC1 Signal Transduction 9.31
bar=donor   line=cohort median 		9.35 35.7%
ACE Signal Transduction 4.39
bar=donor   line=cohort median 		4.64 26.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.5 0
2 B2M 17.2 0
3 ACTB 16.9 0
4 EEF1A1 16.8 0
5 MT-CO1 16.5 0
6 HLA-B 16.3 0
7 HLA-C 16.2 0
8 MT-RNR1 16.1 0
9 HLA-E 16.0 0
10 FTL 16.0 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.3
bar=donor   line=cohort median 		13.8 14.2 60.8%
2 S100A9 15.9
bar=donor   line=cohort median 		15.3 15.5 76.9%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 90.9%
4 CXCL8 10.4
bar=donor   line=cohort median 		10.6 11.4 33.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.4
bar=donor   line=cohort median 		6.0 6.1 67.9%
6 FCGR3B 15.1
bar=donor   line=cohort median 		14.6 14.7 80.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.1
bar=donor   line=cohort median 		14.3 14.3 97.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.0
bar=donor   line=cohort median 		10.2 10.4 12.4%
9 CD3E 11.8
bar=donor   line=cohort median 		11.9 12.0 21.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		11.0 10.9 59.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.7 11.7 51.8%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 34.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 71.1%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.2 15.3 45.7%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.0 15.2 23.1%
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