GSM8077583

Dataset: gse255685 • Sample: YZ800 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 5.6%ile (↓ Low)
22,337 Genes with score > 0 Group median: 22,375 • 8.1%ile (↓ Low)
0 Median expression score Group median: 0 • 0.9%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

44.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.88
bar=donor   line=cohort median 		2.02 27.4%
FOXO3 Insulin/IGF-1 Signaling 10.13
bar=donor   line=cohort median 		9.99 74.0%
CETP Lipid Metabolism 4.53
bar=donor   line=cohort median 		5.05 1.6%
SIRT6 Sirtuin Family 8.45
bar=donor   line=cohort median 		8.34 70.4%
SIRT1 Sirtuin Family 8.73
bar=donor   line=cohort median 		8.72 50.7%
SIRT3 Sirtuin Family 7.37
bar=donor   line=cohort median 		7.49 29.2%
IGF1R Insulin/IGF-1 Signaling 10.27
bar=donor   line=cohort median 		10.21 56.5%
KLOTHO Anti-aging 2.74
bar=donor   line=cohort median 		2.51 80.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 43.6%
IL6 Inflammation 0.99
bar=donor   line=cohort median 		1.16 7.4%
TERT Telomere Maintenance 1.37
bar=donor   line=cohort median 		1.51 18.1%
IRS2 Insulin/IGF-1 Signaling 9.60
bar=donor   line=cohort median 		9.81 29.2%
TP53 Tumor Suppression 9.09
bar=donor   line=cohort median 		8.92 76.9%
SHC1 Signal Transduction 9.34
bar=donor   line=cohort median 		9.35 46.1%
ACE Signal Transduction 4.74
bar=donor   line=cohort median 		4.64 60.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 17.1 0
3 ACTB 16.8 0
4 EEF1A1 16.7 0
5 HLA-C 16.6 0
6 MT-CO1 16.3 0
7 MT-RNR1 16.0 0
8 S100A9 16.0 0
9 HLA-E 15.9 0
10 FTL 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.5
bar=donor   line=cohort median 		13.8 14.2 70.4%
2 S100A9 16.0
bar=donor   line=cohort median 		15.3 15.5 79.0%
3 IL1B 10.2
bar=donor   line=cohort median 		9.5 9.3 93.0%
4 CXCL8 9.8
bar=donor   line=cohort median 		10.6 11.4 24.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.4
bar=donor   line=cohort median 		6.0 6.1 68.6%
6 FCGR3B 15.6
bar=donor   line=cohort median 		14.6 14.7 97.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.9
bar=donor   line=cohort median 		14.3 14.3 89.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.2 10.4 47.5%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 42.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		11.0 10.9 42.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.7 11.7 59.7%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 23.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 25.6%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.2 15.3 32.1%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.0 15.2 31.7%
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