GSM8077585

Dataset: gse255685 • Sample: YZ809 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 66.5%ile (≈ Median)
22,369 Genes with score > 0 Group median: 22,378 • 37.1%ile (≈ Median)
0 Median expression score Group median: 0 • 52.2%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

38.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.77
bar=donor   line=cohort median 		2.02 8.8%
FOXO3 Insulin/IGF-1 Signaling 9.86
bar=donor   line=cohort median 		9.99 31.4%
CETP Lipid Metabolism 5.08
bar=donor   line=cohort median 		5.05 54.7%
SIRT6 Sirtuin Family 8.26
bar=donor   line=cohort median 		8.34 30.3%
SIRT1 Sirtuin Family 8.88
bar=donor   line=cohort median 		8.72 80.5%
SIRT3 Sirtuin Family 7.49
bar=donor   line=cohort median 		7.49 49.6%
IGF1R Insulin/IGF-1 Signaling 10.18
bar=donor   line=cohort median 		10.21 46.8%
KLOTHO Anti-aging 2.61
bar=donor   line=cohort median 		2.51 65.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 14.5%
IL6 Inflammation 1.21
bar=donor   line=cohort median 		1.16 61.5%
TERT Telomere Maintenance 1.27
bar=donor   line=cohort median 		1.51 0.5%
IRS2 Insulin/IGF-1 Signaling 9.56
bar=donor   line=cohort median 		9.81 27.1%
TP53 Tumor Suppression 8.97
bar=donor   line=cohort median 		8.92 59.7%
SHC1 Signal Transduction 9.24
bar=donor   line=cohort median 		9.35 14.5%
ACE Signal Transduction 4.51
bar=donor   line=cohort median 		4.64 37.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 17.0 0
3 EEF1A1 16.6 0
4 ACTB 16.5 0
5 MT-CO1 16.5 0
6 MT-RNR1 16.2 0
7 HLA-B 16.1 0
8 HLA-C 16.1 0
9 HLA-E 15.8 0
10 FTL 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.9
bar=donor   line=cohort median 		14.2 14.2 35.7%
2 S100A9 15.3
bar=donor   line=cohort median 		15.4 15.5 32.8%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 82.6%
4 CXCL8 12.3
bar=donor   line=cohort median 		10.3 11.4 77.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.1 6.1 25.6%
6 FCGR3B 15.3
bar=donor   line=cohort median 		14.7 14.7 91.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 37.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.3 10.4 18.8%
9 CD3E 11.7
bar=donor   line=cohort median 		11.9 12.0 10.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.9
bar=donor   line=cohort median 		10.9 10.9 99.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 28.9%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 22.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 64.7%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.3 15.3 30.3%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 36.4%
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