GSM8077587

Dataset: gse255685 • Sample: YZ811 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 36.4%ile (≈ Median)
22,378 Genes with score > 0 Group median: 22,375 • 50.0%ile (≈ Median)
0 Median expression score Group median: 0 • 37.8%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

45.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.84
bar=donor   line=cohort median 		2.02 21.0%
FOXO3 Insulin/IGF-1 Signaling 9.52
bar=donor   line=cohort median 		9.99 3.1%
CETP Lipid Metabolism 5.34
bar=donor   line=cohort median 		5.05 82.3%
SIRT6 Sirtuin Family 8.30
bar=donor   line=cohort median 		8.34 38.9%
SIRT1 Sirtuin Family 8.74
bar=donor   line=cohort median 		8.72 53.9%
SIRT3 Sirtuin Family 7.47
bar=donor   line=cohort median 		7.49 45.3%
IGF1R Insulin/IGF-1 Signaling 9.89
bar=donor   line=cohort median 		10.21 24.2%
KLOTHO Anti-aging 2.46
bar=donor   line=cohort median 		2.51 43.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 15.6%
IL6 Inflammation 1.78
bar=donor   line=cohort median 		1.16 98.4%
TERT Telomere Maintenance 1.56
bar=donor   line=cohort median 		1.51 60.0%
IRS2 Insulin/IGF-1 Signaling 9.34
bar=donor   line=cohort median 		9.81 12.4%
TP53 Tumor Suppression 9.11
bar=donor   line=cohort median 		8.92 80.5%
SHC1 Signal Transduction 9.45
bar=donor   line=cohort median 		9.35 79.0%
ACE Signal Transduction 4.37
bar=donor   line=cohort median 		4.64 22.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 16.9 0
3 EEF1A1 16.7 0
4 MT-CO1 16.6 0
5 ACTB 16.5 0
6 MT-RNR1 16.2 0
7 HLA-B 15.8 0
8 MT-ND4 15.8 0
9 HLA-C 15.7 0
10 TMSB4X 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.8
bar=donor   line=cohort median 		13.8 14.2 24.9%
2 S100A9 15.1
bar=donor   line=cohort median 		15.3 15.5 22.4%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 51.1%
4 CXCL8 11.4
bar=donor   line=cohort median 		10.6 11.4 51.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.0 6.1 41.4%
6 FCGR3B 14.3
bar=donor   line=cohort median 		14.6 14.7 18.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.7
bar=donor   line=cohort median 		14.3 14.3 8.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.2 10.4 71.9%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 48.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.6
bar=donor   line=cohort median 		11.0 10.9 98.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.2
bar=donor   line=cohort median 		11.7 11.7 79.7%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 37.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 81.9%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.2 15.3 65.8%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.0 15.2 52.5%
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