GSM8077589

Dataset: gse255685 • Sample: YZ815 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 53.2%ile (≈ Median)
22,383 Genes with score > 0 Group median: 22,378 • 57.9%ile (≈ Median)
0 Median expression score Group median: 0 • 74.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.05
bar=donor   line=cohort median 		2.02 56.1%
FOXO3 Insulin/IGF-1 Signaling 9.94
bar=donor   line=cohort median 		9.99 43.9%
CETP Lipid Metabolism 5.03
bar=donor   line=cohort median 		5.05 48.2%
SIRT6 Sirtuin Family 8.33
bar=donor   line=cohort median 		8.34 47.5%
SIRT1 Sirtuin Family 9.00
bar=donor   line=cohort median 		8.72 93.7%
SIRT3 Sirtuin Family 7.46
bar=donor   line=cohort median 		7.49 43.6%
IGF1R Insulin/IGF-1 Signaling 10.34
bar=donor   line=cohort median 		10.21 65.1%
KLOTHO Anti-aging 2.53
bar=donor   line=cohort median 		2.51 52.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 22.0%
IL6 Inflammation 1.07
bar=donor   line=cohort median 		1.16 22.8%
TERT Telomere Maintenance 1.43
bar=donor   line=cohort median 		1.51 30.3%
IRS2 Insulin/IGF-1 Signaling 9.89
bar=donor   line=cohort median 		9.81 56.8%
TP53 Tumor Suppression 8.93
bar=donor   line=cohort median 		8.92 51.8%
SHC1 Signal Transduction 9.47
bar=donor   line=cohort median 		9.35 81.9%
ACE Signal Transduction 5.06
bar=donor   line=cohort median 		4.64 86.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.1 0
2 B2M 16.9 0
3 EEF1A1 16.6 0
4 ACTB 16.3 0
5 MT-CO1 16.3 0
6 HLA-B 15.9 0
7 MT-RNR1 15.7 0
8 HLA-C 15.7 0
9 HLA-E 15.6 0
10 FTL 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.5
bar=donor   line=cohort median 		14.2 14.2 15.2%
2 S100A9 15.0
bar=donor   line=cohort median 		15.4 15.5 12.7%
3 IL1B 9.2
bar=donor   line=cohort median 		9.5 9.3 43.5%
4 CXCL8 12.6
bar=donor   line=cohort median 		10.3 11.4 85.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.2
bar=donor   line=cohort median 		6.1 6.1 90.5%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 34.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.4 14.3 23.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 52.2%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 38.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 58.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.8
bar=donor   line=cohort median 		11.5 11.7 57.2%
12 GNLY 12.1
bar=donor   line=cohort median 		12.0 12.1 50.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 15.9%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.3 15.3 9.5%
18 MT-ND1 14.7
bar=donor   line=cohort median 		15.2 15.2 4.1%
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