GSM8077591

Dataset: gse255685 • Sample: YZ818 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 87.3%ile (↑ High)
22,421 Genes with score > 0 Group median: 22,378 • 89.4%ile (↑ High)
0 Median expression score Group median: 0 • 89.4%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.99
bar=donor   line=cohort median 		2.02 45.3%
FOXO3 Insulin/IGF-1 Signaling 9.87
bar=donor   line=cohort median 		9.99 32.4%
CETP Lipid Metabolism 5.22
bar=donor   line=cohort median 		5.05 72.6%
SIRT6 Sirtuin Family 8.29
bar=donor   line=cohort median 		8.34 37.1%
SIRT1 Sirtuin Family 8.83
bar=donor   line=cohort median 		8.72 73.3%
SIRT3 Sirtuin Family 7.51
bar=donor   line=cohort median 		7.49 53.9%
IGF1R Insulin/IGF-1 Signaling 10.09
bar=donor   line=cohort median 		10.21 37.8%
KLOTHO Anti-aging 3.06
bar=donor   line=cohort median 		2.51 98.0%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 20.3%
IL6 Inflammation 1.14
bar=donor   line=cohort median 		1.16 46.4%
TERT Telomere Maintenance 1.43
bar=donor   line=cohort median 		1.51 29.9%
IRS2 Insulin/IGF-1 Signaling 9.86
bar=donor   line=cohort median 		9.81 53.9%
TP53 Tumor Suppression 8.83
bar=donor   line=cohort median 		8.92 42.5%
SHC1 Signal Transduction 9.23
bar=donor   line=cohort median 		9.35 12.0%
ACE Signal Transduction 5.29
bar=donor   line=cohort median 		4.64 96.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 16.7 0
3 EEF1A1 16.7 0
4 MT-CO1 16.5 0
5 ACTB 16.4 0
6 MT-RNR1 16.1 0
7 CSF3R 15.8 0
8 FTL 15.7 0
9 MT-ND4 15.7 0
10 S100A9 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		14.2 14.2 55.0%
2 S100A9 15.6
bar=donor   line=cohort median 		15.4 15.5 58.6%
3 IL1B 10.5
bar=donor   line=cohort median 		9.5 9.3 98.7%
4 CXCL8 11.9
bar=donor   line=cohort median 		10.3 11.4 66.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.1 6.1 51.8%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.7 14.7 35.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.8
bar=donor   line=cohort median 		14.4 14.3 85.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.3 10.4 16.7%
9 CD3E 11.7
bar=donor   line=cohort median 		11.9 12.0 8.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 66.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.0
bar=donor   line=cohort median 		11.5 11.7 4.8%
12 GNLY 12.0
bar=donor   line=cohort median 		12.0 12.1 41.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 56.8%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.3 15.3 47.1%
18 MT-ND1 15.4
bar=donor   line=cohort median 		15.2 15.2 79.4%
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