GSM8077592

Dataset: gse255685 • Sample: YZ823 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 50.0%ile (≈ Median)
22,365 Genes with score > 0 Group median: 22,375 • 32.8%ile (≈ Median)
0 Median expression score Group median: 0 • 42.8%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

49.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.91
bar=donor   line=cohort median 		2.02 32.8%
FOXO3 Insulin/IGF-1 Signaling 10.01
bar=donor   line=cohort median 		9.99 53.6%
CETP Lipid Metabolism 5.00
bar=donor   line=cohort median 		5.05 44.3%
SIRT6 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.34 44.6%
SIRT1 Sirtuin Family 8.77
bar=donor   line=cohort median 		8.72 61.1%
SIRT3 Sirtuin Family 7.40
bar=donor   line=cohort median 		7.49 33.5%
IGF1R Insulin/IGF-1 Signaling 10.45
bar=donor   line=cohort median 		10.21 77.2%
KLOTHO Anti-aging 3.03
bar=donor   line=cohort median 		2.51 96.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 62.2%
IL6 Inflammation 1.19
bar=donor   line=cohort median 		1.16 57.9%
TERT Telomere Maintenance 1.29
bar=donor   line=cohort median 		1.51 5.6%
IRS2 Insulin/IGF-1 Signaling 9.55
bar=donor   line=cohort median 		9.81 26.0%
TP53 Tumor Suppression 9.05
bar=donor   line=cohort median 		8.92 73.3%
SHC1 Signal Transduction 9.28
bar=donor   line=cohort median 		9.35 26.0%
ACE Signal Transduction 4.54
bar=donor   line=cohort median 		4.64 40.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 16.8 0
3 ACTB 16.7 0
4 EEF1A1 16.6 0
5 MT-CO1 16.5 0
6 HLA-C 16.2 0
7 MT-RNR1 15.9 0
8 HLA-E 15.8 0
9 FTL 15.7 0
10 MT-ND4 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.8
bar=donor   line=cohort median 		13.8 14.2 26.7%
2 S100A9 15.3
bar=donor   line=cohort median 		15.3 15.5 30.3%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 85.1%
4 CXCL8 10.0
bar=donor   line=cohort median 		10.6 11.4 27.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.0 6.1 9.9%
6 FCGR3B 15.1
bar=donor   line=cohort median 		14.6 14.7 79.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.3 14.3 21.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.2 10.4 33.2%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 35.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		11.0 10.9 60.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.2
bar=donor   line=cohort median 		11.7 11.7 78.3%
12 GNLY 12.6
bar=donor   line=cohort median 		12.0 12.1 81.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 76.5%
17 MT-CO2 15.3
bar=donor   line=cohort median 		15.2 15.3 51.1%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.0 15.2 32.1%
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