GSM8077593

Dataset: gse255685 • Sample: YZ825 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 47.1%ile (≈ Median)
22,354 Genes with score > 0 Group median: 22,378 • 18.3%ile (↓ Low)
0 Median expression score Group median: 0 • 19.9%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.21
bar=donor   line=cohort median 		2.02 77.2%
FOXO3 Insulin/IGF-1 Signaling 10.11
bar=donor   line=cohort median 		9.99 69.0%
CETP Lipid Metabolism 5.36
bar=donor   line=cohort median 		5.05 84.1%
SIRT6 Sirtuin Family 8.38
bar=donor   line=cohort median 		8.34 60.0%
SIRT1 Sirtuin Family 8.93
bar=donor   line=cohort median 		8.72 89.1%
SIRT3 Sirtuin Family 7.24
bar=donor   line=cohort median 		7.49 9.5%
IGF1R Insulin/IGF-1 Signaling 10.57
bar=donor   line=cohort median 		10.21 87.6%
KLOTHO Anti-aging 2.28
bar=donor   line=cohort median 		2.51 14.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 16.7%
IL6 Inflammation 1.14
bar=donor   line=cohort median 		1.16 45.3%
TERT Telomere Maintenance 1.62
bar=donor   line=cohort median 		1.51 75.1%
IRS2 Insulin/IGF-1 Signaling 9.75
bar=donor   line=cohort median 		9.81 44.3%
TP53 Tumor Suppression 9.00
bar=donor   line=cohort median 		8.92 62.2%
SHC1 Signal Transduction 9.33
bar=donor   line=cohort median 		9.35 43.6%
ACE Signal Transduction 4.35
bar=donor   line=cohort median 		4.64 19.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 18.0 0
2 B2M 17.1 0
3 ACTB 16.6 0
4 MT-CO1 16.5 0
5 EEF1A1 16.4 0
6 MT-RNR1 16.4 0
7 HLA-C 16.0 0
8 HLA-E 16.0 0
9 HLA-B 16.0 0
10 MT-ND4 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.1
bar=donor   line=cohort median 		14.2 14.2 47.1%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 61.8%
3 IL1B 10.0
bar=donor   line=cohort median 		9.5 9.3 85.5%
4 CXCL8 10.7
bar=donor   line=cohort median 		10.3 11.4 37.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.2
bar=donor   line=cohort median 		6.1 6.1 59.0%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.7 14.7 43.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 72.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 37.1%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 36.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		10.9 10.9 38.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 31.7%
12 GNLY 11.6
bar=donor   line=cohort median 		12.0 12.1 16.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 56.5%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 64.3%
18 MT-ND1 15.6
bar=donor   line=cohort median 		15.2 15.2 88.7%
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