GSM8077596

Dataset: gse255685 • Sample: YZ831 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 64.3%ile (≈ Median)
22,420 Genes with score > 0 Group median: 22,375 • 88.7%ile (↑ High)
0 Median expression score Group median: 0 • 88.7%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

43.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.17
bar=donor   line=cohort median 		2.02 73.3%
FOXO3 Insulin/IGF-1 Signaling 10.12
bar=donor   line=cohort median 		9.99 70.1%
CETP Lipid Metabolism 4.70
bar=donor   line=cohort median 		5.05 12.7%
SIRT6 Sirtuin Family 8.29
bar=donor   line=cohort median 		8.34 36.7%
SIRT1 Sirtuin Family 8.95
bar=donor   line=cohort median 		8.72 90.5%
SIRT3 Sirtuin Family 7.32
bar=donor   line=cohort median 		7.49 19.9%
IGF1R Insulin/IGF-1 Signaling 10.12
bar=donor   line=cohort median 		10.21 40.3%
KLOTHO Anti-aging 2.06
bar=donor   line=cohort median 		2.51 0.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 19.9%
IL6 Inflammation 0.98
bar=donor   line=cohort median 		1.16 3.4%
TERT Telomere Maintenance 1.68
bar=donor   line=cohort median 		1.51 82.6%
IRS2 Insulin/IGF-1 Signaling 10.00
bar=donor   line=cohort median 		9.81 64.7%
TP53 Tumor Suppression 8.96
bar=donor   line=cohort median 		8.92 55.7%
SHC1 Signal Transduction 9.36
bar=donor   line=cohort median 		9.35 57.5%
ACE Signal Transduction 4.32
bar=donor   line=cohort median 		4.64 18.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 B2M 16.9 0
3 EEF1A1 16.7 0
4 ACTB 16.4 0
5 HLA-C 16.2 0
6 MT-CO1 16.1 0
7 MT-RNR1 15.9 0
8 FTL 15.7 0
9 HLA-E 15.7 0
10 CSF3R 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.7
bar=donor   line=cohort median 		13.8 14.2 21.0%
2 S100A9 15.1
bar=donor   line=cohort median 		15.3 15.5 20.3%
3 IL1B 9.1
bar=donor   line=cohort median 		9.5 9.3 40.7%
4 CXCL8 11.6
bar=donor   line=cohort median 		10.6 11.4 56.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.0 6.1 29.2%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.6 14.7 40.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.3
bar=donor   line=cohort median 		14.3 14.3 43.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.2 10.4 52.9%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 49.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		11.0 10.9 57.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.0
bar=donor   line=cohort median 		11.7 11.7 68.3%
12 GNLY 12.6
bar=donor   line=cohort median 		12.0 12.1 79.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.1
bar=donor   line=cohort median 		16.4 16.4 4.5%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.2 15.3 15.6%
18 MT-ND1 14.8
bar=donor   line=cohort median 		15.0 15.2 7.7%
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