GSM8077603

Dataset: gse255685 • Sample: YZ844 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 79.4%ile (↑ High)
22,384 Genes with score > 0 Group median: 22,378 • 59.9%ile (≈ Median)
0 Median expression score Group median: 0 • 52.9%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

47.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.81
bar=donor   line=cohort median 		2.02 16.7%
FOXO3 Insulin/IGF-1 Signaling 10.07
bar=donor   line=cohort median 		9.99 60.8%
CETP Lipid Metabolism 5.09
bar=donor   line=cohort median 		5.05 58.6%
SIRT6 Sirtuin Family 8.15
bar=donor   line=cohort median 		8.34 10.9%
SIRT1 Sirtuin Family 8.75
bar=donor   line=cohort median 		8.72 55.0%
SIRT3 Sirtuin Family 7.20
bar=donor   line=cohort median 		7.49 7.4%
IGF1R Insulin/IGF-1 Signaling 10.52
bar=donor   line=cohort median 		10.21 83.7%
KLOTHO Anti-aging 2.68
bar=donor   line=cohort median 		2.51 72.9%
APOC3 Lipid Metabolism -2.08
bar=donor   line=cohort median 		-2.11 97.0%
IL6 Inflammation 1.42
bar=donor   line=cohort median 		1.16 88.4%
TERT Telomere Maintenance 1.29
bar=donor   line=cohort median 		1.51 4.8%
IRS2 Insulin/IGF-1 Signaling 9.68
bar=donor   line=cohort median 		9.81 36.4%
TP53 Tumor Suppression 8.84
bar=donor   line=cohort median 		8.92 43.2%
SHC1 Signal Transduction 9.25
bar=donor   line=cohort median 		9.35 17.4%
ACE Signal Transduction 4.68
bar=donor   line=cohort median 		4.64 53.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 B2M 17.1 0
3 ACTB 16.5 0
4 EEF1A1 16.5 0
5 MT-RNR1 16.0 0
6 MT-CO1 16.0 0
7 HLA-C 15.9 0
8 HLA-B 15.9 0
9 HLA-E 15.9 0
10 CSF3R 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.4
bar=donor   line=cohort median 		14.2 14.2 64.3%
2 S100A9 15.7
bar=donor   line=cohort median 		15.4 15.5 65.8%
3 IL1B 10.3
bar=donor   line=cohort median 		9.5 9.3 95.5%
4 CXCL8 9.6
bar=donor   line=cohort median 		10.3 11.4 21.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.4
bar=donor   line=cohort median 		6.1 6.1 3.8%
6 FCGR3B 15.4
bar=donor   line=cohort median 		14.7 14.7 92.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.4 14.3 35.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.3 10.4 60.8%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 58.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		10.9 10.9 60.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.5 11.7 49.3%
12 GNLY 12.0
bar=donor   line=cohort median 		12.0 12.1 39.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.0
bar=donor   line=cohort median 		16.4 16.4 1.3%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.3 15.3 8.1%
18 MT-ND1 15.1
bar=donor   line=cohort median 		15.2 15.2 33.2%
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