GSM8077606

Dataset: gse255685 • Sample: YZ851 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 37.1%ile (≈ Median)
22,368 Genes with score > 0 Group median: 22,378 • 35.7%ile (≈ Median)
0 Median expression score Group median: 0 • 50.4%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

56.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.05
bar=donor   line=cohort median 		2.02 55.7%
FOXO3 Insulin/IGF-1 Signaling 9.92
bar=donor   line=cohort median 		9.99 41.0%
CETP Lipid Metabolism 5.46
bar=donor   line=cohort median 		5.05 89.8%
SIRT6 Sirtuin Family 8.39
bar=donor   line=cohort median 		8.34 62.5%
SIRT1 Sirtuin Family 8.93
bar=donor   line=cohort median 		8.72 88.7%
SIRT3 Sirtuin Family 7.31
bar=donor   line=cohort median 		7.49 17.7%
IGF1R Insulin/IGF-1 Signaling 10.33
bar=donor   line=cohort median 		10.21 62.5%
KLOTHO Anti-aging 2.59
bar=donor   line=cohort median 		2.51 62.5%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 84.8%
IL6 Inflammation 1.50
bar=donor   line=cohort median 		1.16 93.4%
TERT Telomere Maintenance 1.31
bar=donor   line=cohort median 		1.51 10.2%
IRS2 Insulin/IGF-1 Signaling 9.63
bar=donor   line=cohort median 		9.81 32.1%
TP53 Tumor Suppression 9.14
bar=donor   line=cohort median 		8.92 86.2%
SHC1 Signal Transduction 9.38
bar=donor   line=cohort median 		9.35 59.3%
ACE Signal Transduction 3.70
bar=donor   line=cohort median 		4.64 0.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.7 0
2 B2M 16.9 0
3 EEF1A1 16.8 0
4 MT-CO1 16.5 0
5 ACTB 16.5 0
6 HLA-C 16.2 0
7 MT-RNR1 16.2 0
8 FTL 16.0 0
9 HLA-B 15.8 0
10 MT-ND4 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.9
bar=donor   line=cohort median 		14.2 14.2 30.6%
2 S100A9 15.3
bar=donor   line=cohort median 		15.4 15.5 33.2%
3 IL1B 9.6
bar=donor   line=cohort median 		9.5 9.3 67.6%
4 CXCL8 10.3
bar=donor   line=cohort median 		10.3 11.4 29.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.1 6.1 55.7%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.7 14.7 39.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.4 14.3 78.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.3
bar=donor   line=cohort median 		10.3 10.4 38.9%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 28.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.5
bar=donor   line=cohort median 		10.9 10.9 97.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.0
bar=donor   line=cohort median 		11.5 11.7 5.6%
12 GNLY 11.3
bar=donor   line=cohort median 		12.0 12.1 2.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 75.8%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.3 15.3 66.1%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 70.8%
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