GSM8077607

Dataset: gse255685 • Sample: YZ855 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 98.0%ile (↑ High)
22,408 Genes with score > 0 Group median: 22,378 • 81.9%ile (↑ High)
0 Median expression score Group median: 0 • 87.6%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

61.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.44
bar=donor   line=cohort median 		2.02 90.5%
FOXO3 Insulin/IGF-1 Signaling 9.91
bar=donor   line=cohort median 		9.99 37.5%
CETP Lipid Metabolism 5.26
bar=donor   line=cohort median 		5.05 77.6%
SIRT6 Sirtuin Family 8.45
bar=donor   line=cohort median 		8.34 71.2%
SIRT1 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.72 7.7%
SIRT3 Sirtuin Family 7.35
bar=donor   line=cohort median 		7.49 26.0%
IGF1R Insulin/IGF-1 Signaling 10.48
bar=donor   line=cohort median 		10.21 80.1%
KLOTHO Anti-aging 2.79
bar=donor   line=cohort median 		2.51 85.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 45.3%
IL6 Inflammation 1.09
bar=donor   line=cohort median 		1.16 30.3%
TERT Telomere Maintenance 1.60
bar=donor   line=cohort median 		1.51 71.2%
IRS2 Insulin/IGF-1 Signaling 10.50
bar=donor   line=cohort median 		9.81 84.1%
TP53 Tumor Suppression 8.94
bar=donor   line=cohort median 		8.92 52.9%
SHC1 Signal Transduction 9.50
bar=donor   line=cohort median 		9.35 87.3%
ACE Signal Transduction 4.95
bar=donor   line=cohort median 		4.64 79.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 DPP6 76.8 0
2 MT-RNR2 17.5 0
3 B2M 16.9 0
4 ACTB 16.6 0
5 MT-CO1 16.6 0
6 EEF1A1 16.5 0
7 HLA-C 16.3 0
8 FTL 15.9 0
9 MT-RNR1 15.9 0
10 HLA-E 15.9 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.2
bar=donor   line=cohort median 		14.2 14.2 48.6%
2 S100A9 15.5
bar=donor   line=cohort median 		15.4 15.5 49.3%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 57.2%
4 CXCL8 12.6
bar=donor   line=cohort median 		10.3 11.4 86.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.6
bar=donor   line=cohort median 		6.1 6.1 76.5%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.7 14.7 43.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.7
bar=donor   line=cohort median 		14.4 14.3 78.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.3 10.4 22.0%
9 CD3E 11.6
bar=donor   line=cohort median 		11.9 12.0 6.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 51.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 25.3%
12 GNLY 11.7
bar=donor   line=cohort median 		12.0 12.1 17.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 80.5%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.3 15.3 69.0%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.2 15.2 39.2%
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