GSM8077609

Dataset: gse255685 • Sample: YZ857 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 69.7%ile (≈ Median)
22,396 Genes with score > 0 Group median: 22,378 • 72.0%ile (≈ Median)
0 Median expression score Group median: 0 • 83.3%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

49.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.70
bar=donor   line=cohort median 		2.02 2.0%
FOXO3 Insulin/IGF-1 Signaling 9.92
bar=donor   line=cohort median 		9.99 41.8%
CETP Lipid Metabolism 4.97
bar=donor   line=cohort median 		5.05 40.7%
SIRT6 Sirtuin Family 8.23
bar=donor   line=cohort median 		8.34 23.1%
SIRT1 Sirtuin Family 8.84
bar=donor   line=cohort median 		8.72 74.0%
SIRT3 Sirtuin Family 7.49
bar=donor   line=cohort median 		7.49 50.4%
IGF1R Insulin/IGF-1 Signaling 10.24
bar=donor   line=cohort median 		10.21 52.5%
KLOTHO Anti-aging 2.38
bar=donor   line=cohort median 		2.51 32.4%
APOC3 Lipid Metabolism -2.08
bar=donor   line=cohort median 		-2.11 95.5%
IL6 Inflammation 1.08
bar=donor   line=cohort median 		1.16 29.2%
TERT Telomere Maintenance 1.45
bar=donor   line=cohort median 		1.51 36.4%
IRS2 Insulin/IGF-1 Signaling 9.79
bar=donor   line=cohort median 		9.81 47.9%
TP53 Tumor Suppression 9.18
bar=donor   line=cohort median 		8.92 91.2%
SHC1 Signal Transduction 9.38
bar=donor   line=cohort median 		9.35 62.9%
ACE Signal Transduction 4.72
bar=donor   line=cohort median 		4.64 58.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.3 0
2 EEF1A1 16.8 0
3 B2M 16.7 0
4 MT-CO1 16.6 0
5 ACTB 16.4 0
6 MT-ND4 16.0 0
7 HLA-C 15.9 0
8 MT-RNR1 15.9 0
9 HLA-E 15.6 0
10 FTL 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.4
bar=donor   line=cohort median 		14.2 14.2 13.1%
2 S100A9 15.0
bar=donor   line=cohort median 		15.4 15.5 12.4%
3 IL1B 8.8
bar=donor   line=cohort median 		9.5 9.3 31.4%
4 CXCL8 12.2
bar=donor   line=cohort median 		10.3 11.4 75.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.8
bar=donor   line=cohort median 		6.1 6.1 84.8%
6 FCGR3B 13.6
bar=donor   line=cohort median 		14.7 14.7 2.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.4
bar=donor   line=cohort median 		14.4 14.3 53.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.3 10.4 25.3%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 36.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		10.9 10.9 87.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.0
bar=donor   line=cohort median 		11.5 11.7 3.0%
12 GNLY 11.5
bar=donor   line=cohort median 		12.0 12.1 10.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 80.8%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.3 15.3 76.2%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.2 15.2 65.1%
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