GSM8077610

Dataset: gse255685 • Sample: YZ888 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 4.8%ile (↓ Low)
22,350 Genes with score > 0 Group median: 22,375 • 14.5%ile (↓ Low)
0 Median expression score Group median: 0 • 39.6%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.86
bar=donor   line=cohort median 		2.02 23.1%
FOXO3 Insulin/IGF-1 Signaling 9.74
bar=donor   line=cohort median 		9.99 19.5%
CETP Lipid Metabolism 5.74
bar=donor   line=cohort median 		5.05 96.6%
SIRT6 Sirtuin Family 8.60
bar=donor   line=cohort median 		8.34 86.9%
SIRT1 Sirtuin Family 8.39
bar=donor   line=cohort median 		8.72 10.6%
SIRT3 Sirtuin Family 7.73
bar=donor   line=cohort median 		7.49 88.7%
IGF1R Insulin/IGF-1 Signaling 10.02
bar=donor   line=cohort median 		10.21 33.2%
KLOTHO Anti-aging 2.30
bar=donor   line=cohort median 		2.51 17.0%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 28.5%
IL6 Inflammation 1.07
bar=donor   line=cohort median 		1.16 25.6%
TERT Telomere Maintenance 1.51
bar=donor   line=cohort median 		1.51 48.9%
IRS2 Insulin/IGF-1 Signaling 9.24
bar=donor   line=cohort median 		9.81 7.0%
TP53 Tumor Suppression 9.37
bar=donor   line=cohort median 		8.92 98.4%
SHC1 Signal Transduction 9.60
bar=donor   line=cohort median 		9.35 93.7%
ACE Signal Transduction 5.05
bar=donor   line=cohort median 		4.64 86.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.6 0
2 MT-CO1 16.6 0
3 MT-RNR2 16.5 0
4 EEF1A1 16.4 0
5 B2M 16.3 0
6 HLA-C 16.0 0
7 HLA-E 16.0 0
8 HLA-B 15.8 0
9 CSF3R 15.7 0
10 MT-ND4 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.6
bar=donor   line=cohort median 		13.8 14.2 5.2%
2 S100A9 14.6
bar=donor   line=cohort median 		15.3 15.5 3.4%
3 IL1B 9.4
bar=donor   line=cohort median 		9.5 9.3 54.3%
4 CXCL8 8.4
bar=donor   line=cohort median 		10.6 11.4 3.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.0 6.1 49.3%
6 FCGR3B 14.0
bar=donor   line=cohort median 		14.6 14.7 8.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.3 14.3 21.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.2 10.4 29.6%
9 CD3E 12.4
bar=donor   line=cohort median 		11.9 12.0 91.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.4
bar=donor   line=cohort median 		11.0 10.9 7.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.1
bar=donor   line=cohort median 		11.7 11.7 72.2%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 71.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 78.0%
17 MT-CO2 15.2
bar=donor   line=cohort median 		15.2 15.3 34.6%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.0 15.2 23.8%
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