GSM8077611

Dataset: gse255685 • Sample: YZ893 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 10.9%ile (↓ Low)
22,364 Genes with score > 0 Group median: 22,378 • 31.7%ile (≈ Median)
0 Median expression score Group median: 0 • 22.8%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

60.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.89
bar=donor   line=cohort median 		2.02 28.5%
FOXO3 Insulin/IGF-1 Signaling 10.00
bar=donor   line=cohort median 		9.99 50.7%
CETP Lipid Metabolism 5.85
bar=donor   line=cohort median 		5.05 97.7%
SIRT6 Sirtuin Family 8.65
bar=donor   line=cohort median 		8.34 89.4%
SIRT1 Sirtuin Family 8.49
bar=donor   line=cohort median 		8.72 19.9%
SIRT3 Sirtuin Family 7.76
bar=donor   line=cohort median 		7.49 93.0%
IGF1R Insulin/IGF-1 Signaling 10.58
bar=donor   line=cohort median 		10.21 88.0%
KLOTHO Anti-aging 2.78
bar=donor   line=cohort median 		2.51 84.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 5.9%
IL6 Inflammation 1.12
bar=donor   line=cohort median 		1.16 38.9%
TERT Telomere Maintenance 1.47
bar=donor   line=cohort median 		1.51 41.4%
IRS2 Insulin/IGF-1 Signaling 9.95
bar=donor   line=cohort median 		9.81 60.8%
TP53 Tumor Suppression 9.18
bar=donor   line=cohort median 		8.92 91.6%
SHC1 Signal Transduction 9.62
bar=donor   line=cohort median 		9.35 95.5%
ACE Signal Transduction 4.35
bar=donor   line=cohort median 		4.64 20.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.7 0
2 HLA-C 16.7 0
3 MT-CO1 16.3 0
4 HLA-B 16.1 0
5 B2M 16.1 0
6 HLA-E 16.0 0
7 CSF3R 16.0 0
8 MT-RNR2 16.0 0
9 EEF1A1 16.0 0
10 TXNIP 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.2
bar=donor   line=cohort median 		14.2 14.2 2.3%
2 S100A9 15.0
bar=donor   line=cohort median 		15.4 15.5 14.5%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 61.5%
4 CXCL8 8.6
bar=donor   line=cohort median 		10.3 11.4 5.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.1 6.1 53.6%
6 FCGR3B 15.1
bar=donor   line=cohort median 		14.7 14.7 78.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.1
bar=donor   line=cohort median 		14.4 14.3 98.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.6
bar=donor   line=cohort median 		10.3 10.4 2.3%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 70.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.6
bar=donor   line=cohort median 		10.9 10.9 20.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.3
bar=donor   line=cohort median 		11.5 11.7 18.1%
12 GNLY 11.6
bar=donor   line=cohort median 		12.0 12.1 14.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 14.2%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.3 15.3 11.3%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.2 15.2 11.3%
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