GSM8077614

Dataset: gse255685 • Sample: YZ900 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 23.8%ile (↓ Low)
22,385 Genes with score > 0 Group median: 22,378 • 61.8%ile (≈ Median)
0 Median expression score Group median: 0 • 27.4%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

60.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.94
bar=donor   line=cohort median 		2.02 38.2%
FOXO3 Insulin/IGF-1 Signaling 10.11
bar=donor   line=cohort median 		9.99 69.4%
CETP Lipid Metabolism 5.65
bar=donor   line=cohort median 		5.05 94.8%
SIRT6 Sirtuin Family 8.41
bar=donor   line=cohort median 		8.34 65.1%
SIRT1 Sirtuin Family 8.47
bar=donor   line=cohort median 		8.72 17.7%
SIRT3 Sirtuin Family 7.77
bar=donor   line=cohort median 		7.49 93.4%
IGF1R Insulin/IGF-1 Signaling 10.70
bar=donor   line=cohort median 		10.21 95.5%
KLOTHO Anti-aging 2.71
bar=donor   line=cohort median 		2.51 77.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 33.5%
IL6 Inflammation 0.99
bar=donor   line=cohort median 		1.16 5.2%
TERT Telomere Maintenance 1.52
bar=donor   line=cohort median 		1.51 50.7%
IRS2 Insulin/IGF-1 Signaling 9.81
bar=donor   line=cohort median 		9.81 50.0%
TP53 Tumor Suppression 9.14
bar=donor   line=cohort median 		8.92 85.8%
SHC1 Signal Transduction 9.66
bar=donor   line=cohort median 		9.35 96.6%
ACE Signal Transduction 4.51
bar=donor   line=cohort median 		4.64 37.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.7 0
2 B2M 16.4 0
3 EEF1A1 16.2 0
4 MT-RNR2 16.2 0
5 MT-CO1 16.1 0
6 HLA-C 16.0 0
7 HLA-E 15.9 0
8 CSF3R 15.9 0
9 HLA-B 15.9 0
10 TXNIP 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.8
bar=donor   line=cohort median 		14.2 14.2 8.1%
2 S100A9 14.9
bar=donor   line=cohort median 		15.4 15.5 9.9%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 81.2%
4 CXCL8 8.8
bar=donor   line=cohort median 		10.3 11.4 9.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 7.0
bar=donor   line=cohort median 		6.1 6.1 87.6%
6 FCGR3B 15.4
bar=donor   line=cohort median 		14.7 14.7 95.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.9
bar=donor   line=cohort median 		14.4 14.3 91.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.8
bar=donor   line=cohort median 		10.3 10.4 5.6%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 54.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.7
bar=donor   line=cohort median 		10.9 10.9 25.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.6
bar=donor   line=cohort median 		11.5 11.7 44.6%
12 GNLY 12.1
bar=donor   line=cohort median 		12.0 12.1 47.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.1
bar=donor   line=cohort median 		16.4 16.4 6.3%
17 MT-CO2 14.8
bar=donor   line=cohort median 		15.3 15.3 2.7%
18 MT-ND1 14.7
bar=donor   line=cohort median 		15.2 15.2 5.2%
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