GSM8077615

Dataset: gse255685 • Sample: YZ903 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 15.9%ile (↓ Low)
22,376 Genes with score > 0 Group median: 22,378 • 46.8%ile (≈ Median)
0 Median expression score Group median: 0 • 23.5%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

53.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.88
bar=donor   line=cohort median 		2.02 26.3%
FOXO3 Insulin/IGF-1 Signaling 9.84
bar=donor   line=cohort median 		9.99 27.4%
CETP Lipid Metabolism 5.39
bar=donor   line=cohort median 		5.05 86.2%
SIRT6 Sirtuin Family 8.35
bar=donor   line=cohort median 		8.34 54.7%
SIRT1 Sirtuin Family 8.44
bar=donor   line=cohort median 		8.72 14.9%
SIRT3 Sirtuin Family 7.85
bar=donor   line=cohort median 		7.49 98.0%
IGF1R Insulin/IGF-1 Signaling 10.47
bar=donor   line=cohort median 		10.21 79.8%
KLOTHO Anti-aging 2.87
bar=donor   line=cohort median 		2.51 89.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 41.0%
IL6 Inflammation 0.99
bar=donor   line=cohort median 		1.16 7.0%
TERT Telomere Maintenance 1.45
bar=donor   line=cohort median 		1.51 37.1%
IRS2 Insulin/IGF-1 Signaling 9.46
bar=donor   line=cohort median 		9.81 18.5%
TP53 Tumor Suppression 9.21
bar=donor   line=cohort median 		8.92 93.7%
SHC1 Signal Transduction 9.62
bar=donor   line=cohort median 		9.35 94.4%
ACE Signal Transduction 4.50
bar=donor   line=cohort median 		4.64 36.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.6 0
2 MT-CO1 16.4 0
3 MT-RNR2 16.2 0
4 B2M 16.2 0
5 EEF1A1 16.1 0
6 CSF3R 16.0 0
7 HLA-C 16.0 0
8 HLA-B 15.9 0
9 HLA-E 15.9 0
10 FTL 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.7
bar=donor   line=cohort median 		14.2 14.2 6.6%
2 S100A9 15.0
bar=donor   line=cohort median 		15.4 15.5 13.8%
3 IL1B 10.0
bar=donor   line=cohort median 		9.5 9.3 88.0%
4 CXCL8 8.5
bar=donor   line=cohort median 		10.3 11.4 5.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.6
bar=donor   line=cohort median 		6.1 6.1 75.4%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.7 14.7 88.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.9
bar=donor   line=cohort median 		14.4 14.3 18.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.8
bar=donor   line=cohort median 		10.3 10.4 5.2%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 56.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.5
bar=donor   line=cohort median 		10.9 10.9 14.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.1
bar=donor   line=cohort median 		11.5 11.7 74.0%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 70.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 37.8%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.3 15.3 9.9%
18 MT-ND1 14.8
bar=donor   line=cohort median 		15.2 15.2 8.8%
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