GSM8077618

Dataset: gse255685 • Sample: YZ940 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 14.9%ile (↓ Low)
22,361 Genes with score > 0 Group median: 22,375 • 27.4%ile (≈ Median)
0 Median expression score Group median: 0 • 24.6%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

55.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.84
bar=donor   line=cohort median 		2.02 19.9%
FOXO3 Insulin/IGF-1 Signaling 9.92
bar=donor   line=cohort median 		9.99 39.6%
CETP Lipid Metabolism 5.38
bar=donor   line=cohort median 		5.05 85.8%
SIRT6 Sirtuin Family 8.57
bar=donor   line=cohort median 		8.34 84.4%
SIRT1 Sirtuin Family 8.48
bar=donor   line=cohort median 		8.72 19.2%
SIRT3 Sirtuin Family 7.83
bar=donor   line=cohort median 		7.49 96.6%
IGF1R Insulin/IGF-1 Signaling 10.34
bar=donor   line=cohort median 		10.21 67.2%
KLOTHO Anti-aging 2.74
bar=donor   line=cohort median 		2.51 81.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 13.1%
IL6 Inflammation 0.98
bar=donor   line=cohort median 		1.16 3.1%
TERT Telomere Maintenance 1.67
bar=donor   line=cohort median 		1.51 80.5%
IRS2 Insulin/IGF-1 Signaling 9.46
bar=donor   line=cohort median 		9.81 18.8%
TP53 Tumor Suppression 9.46
bar=donor   line=cohort median 		8.92 99.8%
SHC1 Signal Transduction 9.66
bar=donor   line=cohort median 		9.35 97.0%
ACE Signal Transduction 4.45
bar=donor   line=cohort median 		4.64 31.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.6 0
2 MT-CO1 16.4 0
3 HLA-C 16.4 0
4 B2M 16.2 0
5 MT-RNR2 16.1 0
6 EEF1A1 16.1 0
7 CSF3R 16.1 0
8 HLA-E 15.9 0
9 HLA-B 15.7 0
10 CD74 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.8
bar=donor   line=cohort median 		13.8 14.2 7.3%
2 S100A9 14.8
bar=donor   line=cohort median 		15.3 15.5 8.8%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 88.7%
4 CXCL8 8.7
bar=donor   line=cohort median 		10.6 11.4 8.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.9
bar=donor   line=cohort median 		6.0 6.1 39.2%
6 FCGR3B 15.3
bar=donor   line=cohort median 		14.6 14.7 88.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.9
bar=donor   line=cohort median 		14.3 14.3 91.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.9
bar=donor   line=cohort median 		10.2 10.4 7.0%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 79.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		11.0 10.9 71.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.7 11.7 24.6%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 4.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 51.1%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.2 15.3 7.3%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.0 15.2 14.5%
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