GSM8077620

Dataset: gse255685 • Sample: YZ946 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 6.3%ile (↓ Low)
22,356 Genes with score > 0 Group median: 22,378 • 21.5%ile (↓ Low)
0 Median expression score Group median: 0 • 15.9%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

61.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.12
bar=donor   line=cohort median 		2.02 67.6%
FOXO3 Insulin/IGF-1 Signaling 9.99
bar=donor   line=cohort median 		9.99 50.4%
CETP Lipid Metabolism 5.67
bar=donor   line=cohort median 		5.05 95.5%
SIRT6 Sirtuin Family 8.50
bar=donor   line=cohort median 		8.34 78.0%
SIRT1 Sirtuin Family 8.60
bar=donor   line=cohort median 		8.72 35.3%
SIRT3 Sirtuin Family 7.66
bar=donor   line=cohort median 		7.49 79.4%
IGF1R Insulin/IGF-1 Signaling 10.77
bar=donor   line=cohort median 		10.21 97.3%
KLOTHO Anti-aging 2.11
bar=donor   line=cohort median 		2.51 2.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 7.0%
IL6 Inflammation 1.12
bar=donor   line=cohort median 		1.16 39.6%
TERT Telomere Maintenance 1.64
bar=donor   line=cohort median 		1.51 78.0%
IRS2 Insulin/IGF-1 Signaling 9.56
bar=donor   line=cohort median 		9.81 26.7%
TP53 Tumor Suppression 9.27
bar=donor   line=cohort median 		8.92 96.2%
SHC1 Signal Transduction 9.71
bar=donor   line=cohort median 		9.35 98.8%
ACE Signal Transduction 4.77
bar=donor   line=cohort median 		4.64 63.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.7 0
2 HLA-C 16.6 0
3 MT-CO1 16.3 0
4 CSF3R 16.2 0
5 B2M 16.2 0
6 EEF1A1 16.1 0
7 HLA-B 16.1 0
8 HLA-E 16.1 0
9 MT-RNR2 16.0 0
10 TXNIP 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.6
bar=donor   line=cohort median 		14.2 14.2 5.9%
2 S100A9 14.8
bar=donor   line=cohort median 		15.4 15.5 6.6%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 89.8%
4 CXCL8 8.5
bar=donor   line=cohort median 		10.3 11.4 4.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.5
bar=donor   line=cohort median 		6.1 6.1 74.4%
6 FCGR3B 14.3
bar=donor   line=cohort median 		14.7 14.7 19.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.0
bar=donor   line=cohort median 		14.4 14.3 92.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.6
bar=donor   line=cohort median 		10.3 10.4 3.0%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 58.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 50.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.5 11.7 33.2%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 28.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 25.3%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.3 15.3 8.4%
18 MT-ND1 14.4
bar=donor   line=cohort median 		15.2 15.2 0.9%
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