GSM8077623

Dataset: gse255685 • Sample: YZ957 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 4.1%ile (↓ Low)
22,350 Genes with score > 0 Group median: 22,378 • 14.5%ile (↓ Low)
0 Median expression score Group median: 0 • 21.3%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

51.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.92
bar=donor   line=cohort median 		2.02 34.2%
FOXO3 Insulin/IGF-1 Signaling 9.95
bar=donor   line=cohort median 		9.99 44.3%
CETP Lipid Metabolism 5.65
bar=donor   line=cohort median 		5.05 95.2%
SIRT6 Sirtuin Family 8.59
bar=donor   line=cohort median 		8.34 85.8%
SIRT1 Sirtuin Family 8.41
bar=donor   line=cohort median 		8.72 11.7%
SIRT3 Sirtuin Family 7.55
bar=donor   line=cohort median 		7.49 60.8%
IGF1R Insulin/IGF-1 Signaling 10.16
bar=donor   line=cohort median 		10.21 44.6%
KLOTHO Anti-aging 2.21
bar=donor   line=cohort median 		2.51 10.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 17.4%
IL6 Inflammation 1.07
bar=donor   line=cohort median 		1.16 22.0%
TERT Telomere Maintenance 1.56
bar=donor   line=cohort median 		1.51 60.4%
IRS2 Insulin/IGF-1 Signaling 9.39
bar=donor   line=cohort median 		9.81 15.2%
TP53 Tumor Suppression 9.41
bar=donor   line=cohort median 		8.92 99.1%
SHC1 Signal Transduction 9.83
bar=donor   line=cohort median 		9.35 99.5%
ACE Signal Transduction 4.93
bar=donor   line=cohort median 		4.64 78.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.8 0
2 MT-CO1 16.6 0
3 HLA-C 16.6 0
4 B2M 16.3 0
5 MT-RNR2 16.3 0
6 CSF3R 16.2 0
7 EEF1A1 16.2 0
8 HLA-E 16.1 0
9 HLA-B 16.0 0
10 CD74 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.7
bar=donor   line=cohort median 		14.2 14.2 7.0%
2 S100A9 15.0
bar=donor   line=cohort median 		15.4 15.5 12.0%
3 IL1B 10.2
bar=donor   line=cohort median 		9.5 9.3 91.9%
4 CXCL8 8.2
bar=donor   line=cohort median 		10.3 11.4 0.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.1 6.1 29.6%
6 FCGR3B 15.1
bar=donor   line=cohort median 		14.7 14.7 76.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.1
bar=donor   line=cohort median 		14.4 14.3 99.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.7
bar=donor   line=cohort median 		10.3 10.4 4.5%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 84.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.5
bar=donor   line=cohort median 		10.9 10.9 15.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.9
bar=donor   line=cohort median 		11.5 11.7 66.8%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 65.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 88.0%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.3 15.3 14.9%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.2 15.2 16.7%
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