GSM8077624

Dataset: gse255685 • Sample: YZ962 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 9.9%ile (↓ Low)
22,406 Genes with score > 0 Group median: 22,375 • 80.3%ile (↑ High)
0 Median expression score Group median: 0 • 75.8%ile (↑ High)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

62.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.04
bar=donor   line=cohort median 		2.02 53.6%
FOXO3 Insulin/IGF-1 Signaling 9.89
bar=donor   line=cohort median 		9.99 35.0%
CETP Lipid Metabolism 5.54
bar=donor   line=cohort median 		5.05 92.3%
SIRT6 Sirtuin Family 8.35
bar=donor   line=cohort median 		8.34 53.9%
SIRT1 Sirtuin Family 8.55
bar=donor   line=cohort median 		8.72 26.0%
SIRT3 Sirtuin Family 7.91
bar=donor   line=cohort median 		7.49 99.1%
IGF1R Insulin/IGF-1 Signaling 10.26
bar=donor   line=cohort median 		10.21 55.7%
KLOTHO Anti-aging 2.44
bar=donor   line=cohort median 		2.51 41.8%
APOC3 Lipid Metabolism -2.12
bar=donor   line=cohort median 		-2.11 3.4%
IL6 Inflammation 1.34
bar=donor   line=cohort median 		1.16 83.0%
TERT Telomere Maintenance 1.92
bar=donor   line=cohort median 		1.51 97.3%
IRS2 Insulin/IGF-1 Signaling 9.53
bar=donor   line=cohort median 		9.81 24.2%
TP53 Tumor Suppression 9.21
bar=donor   line=cohort median 		8.92 94.1%
SHC1 Signal Transduction 9.59
bar=donor   line=cohort median 		9.35 92.7%
ACE Signal Transduction 5.05
bar=donor   line=cohort median 		4.64 85.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.5 0
2 EEF1A1 16.3 0
3 MT-CO1 16.1 0
4 B2M 16.0 0
5 MT-RNR2 16.0 0
6 HLA-B 15.7 0
7 HLA-E 15.7 0
8 HLA-C 15.6 0
9 CSF3R 15.6 0
10 TXNIP 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.2
bar=donor   line=cohort median 		13.8 14.2 2.7%
2 S100A9 14.5
bar=donor   line=cohort median 		15.3 15.5 2.3%
3 IL1B 8.8
bar=donor   line=cohort median 		9.5 9.3 29.9%
4 CXCL8 8.5
bar=donor   line=cohort median 		10.6 11.4 4.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.0
bar=donor   line=cohort median 		6.0 6.1 45.7%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.6 14.7 26.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.9
bar=donor   line=cohort median 		14.3 14.3 16.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.9
bar=donor   line=cohort median 		10.2 10.4 9.1%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 85.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.6
bar=donor   line=cohort median 		11.0 10.9 17.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.7 11.7 31.0%
12 GNLY 11.8
bar=donor   line=cohort median 		12.0 12.1 21.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.1
bar=donor   line=cohort median 		16.4 16.4 5.2%
17 MT-CO2 14.7
bar=donor   line=cohort median 		15.2 15.3 0.9%
18 MT-ND1 14.5
bar=donor   line=cohort median 		15.0 15.2 1.6%
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