GSM8077626

Dataset: gse255685 • Sample: YZ980 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 32.8%ile (≈ Median)
22,370 Genes with score > 0 Group median: 22,375 • 38.9%ile (≈ Median)
0 Median expression score Group median: 0 • 56.8%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

69.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.08
bar=donor   line=cohort median 		2.02 60.0%
FOXO3 Insulin/IGF-1 Signaling 10.22
bar=donor   line=cohort median 		9.99 85.1%
CETP Lipid Metabolism 5.71
bar=donor   line=cohort median 		5.05 96.2%
SIRT6 Sirtuin Family 8.46
bar=donor   line=cohort median 		8.34 72.6%
SIRT1 Sirtuin Family 8.78
bar=donor   line=cohort median 		8.72 62.5%
SIRT3 Sirtuin Family 7.72
bar=donor   line=cohort median 		7.49 87.3%
IGF1R Insulin/IGF-1 Signaling 10.46
bar=donor   line=cohort median 		10.21 78.7%
KLOTHO Anti-aging 2.58
bar=donor   line=cohort median 		2.51 61.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 67.2%
IL6 Inflammation 1.11
bar=donor   line=cohort median 		1.16 35.3%
TERT Telomere Maintenance 1.48
bar=donor   line=cohort median 		1.51 44.3%
IRS2 Insulin/IGF-1 Signaling 9.72
bar=donor   line=cohort median 		9.81 40.3%
TP53 Tumor Suppression 9.15
bar=donor   line=cohort median 		8.92 87.6%
SHC1 Signal Transduction 9.51
bar=donor   line=cohort median 		9.35 87.6%
ACE Signal Transduction 4.83
bar=donor   line=cohort median 		4.64 69.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.5 0
2 B2M 16.3 0
3 MT-RNR2 16.2 0
4 HLA-C 16.2 0
5 CSF3R 16.2 0
6 EEF1A1 16.2 0
7 MT-CO1 16.1 0
8 HLA-B 16.0 0
9 HLA-E 16.0 0
10 FKBP8 15.7 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.8
bar=donor   line=cohort median 		13.8 14.2 7.7%
2 S100A9 15.0
bar=donor   line=cohort median 		15.3 15.5 15.6%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 84.4%
4 CXCL8 8.9
bar=donor   line=cohort median 		10.6 11.4 10.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.9
bar=donor   line=cohort median 		6.0 6.1 33.9%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.6 14.7 25.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.8
bar=donor   line=cohort median 		14.3 14.3 83.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.9
bar=donor   line=cohort median 		10.2 10.4 6.6%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 60.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.0
bar=donor   line=cohort median 		11.0 10.9 67.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.7 11.7 38.2%
12 GNLY 11.6
bar=donor   line=cohort median 		12.0 12.1 12.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.1
bar=donor   line=cohort median 		16.4 16.4 5.6%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.2 15.3 4.5%
18 MT-ND1 14.5
bar=donor   line=cohort median 		15.0 15.2 2.0%
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