GSM8077627

Dataset: gse255685 • Sample: YZ983 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 3.0%ile (↓ Low)
22,380 Genes with score > 0 Group median: 22,375 • 53.8%ile (≈ Median)
0 Median expression score Group median: 0 • 35.7%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

52.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.00
bar=donor   line=cohort median 		2.02 47.9%
FOXO3 Insulin/IGF-1 Signaling 9.88
bar=donor   line=cohort median 		9.99 33.2%
CETP Lipid Metabolism 5.38
bar=donor   line=cohort median 		5.05 85.5%
SIRT6 Sirtuin Family 8.30
bar=donor   line=cohort median 		8.34 38.2%
SIRT1 Sirtuin Family 8.69
bar=donor   line=cohort median 		8.72 46.8%
SIRT3 Sirtuin Family 7.75
bar=donor   line=cohort median 		7.49 91.2%
IGF1R Insulin/IGF-1 Signaling 10.11
bar=donor   line=cohort median 		10.21 39.6%
KLOTHO Anti-aging 2.45
bar=donor   line=cohort median 		2.51 42.8%
APOC3 Lipid Metabolism -2.12
bar=donor   line=cohort median 		-2.11 0.2%
IL6 Inflammation 1.31
bar=donor   line=cohort median 		1.16 78.3%
TERT Telomere Maintenance 1.58
bar=donor   line=cohort median 		1.51 66.1%
IRS2 Insulin/IGF-1 Signaling 9.34
bar=donor   line=cohort median 		9.81 12.0%
TP53 Tumor Suppression 9.33
bar=donor   line=cohort median 		8.92 97.3%
SHC1 Signal Transduction 9.63
bar=donor   line=cohort median 		9.35 95.9%
ACE Signal Transduction 4.30
bar=donor   line=cohort median 		4.64 16.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.5 0
2 MT-CO1 16.2 0
3 EEF1A1 16.2 0
4 HLA-C 16.2 0
5 B2M 15.8 0
6 MT-RNR2 15.8 0
7 HLA-E 15.7 0
8 HLA-B 15.6 0
9 CSF3R 15.5 0
10 CD74 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.0
bar=donor   line=cohort median 		13.8 14.2 0.9%
2 S100A9 14.2
bar=donor   line=cohort median 		15.3 15.5 0.2%
3 IL1B 8.8
bar=donor   line=cohort median 		9.5 9.3 30.3%
4 CXCL8 8.4
bar=donor   line=cohort median 		10.6 11.4 3.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.0 6.1 5.2%
6 FCGR3B 14.3
bar=donor   line=cohort median 		14.6 14.7 19.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.0
bar=donor   line=cohort median 		14.3 14.3 26.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.8
bar=donor   line=cohort median 		10.2 10.4 4.8%
9 CD3E 12.2
bar=donor   line=cohort median 		11.9 12.0 83.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		11.0 10.9 89.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.6
bar=donor   line=cohort median 		11.7 11.7 42.8%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 66.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 12.4%
17 MT-CO2 14.7
bar=donor   line=cohort median 		15.2 15.3 1.3%
18 MT-ND1 14.6
bar=donor   line=cohort median 		15.0 15.2 2.3%
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