GSM8077628

Dataset: gse255685 • Sample: YZ999 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 2.3%ile (↓ Low)
22,362 Genes with score > 0 Group median: 22,378 • 29.0%ile (≈ Median)
0 Median expression score Group median: 0 • 22.4%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

60.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.86
bar=donor   line=cohort median 		2.02 23.8%
FOXO3 Insulin/IGF-1 Signaling 10.10
bar=donor   line=cohort median 		9.99 67.2%
CETP Lipid Metabolism 5.18
bar=donor   line=cohort median 		5.05 69.0%
SIRT6 Sirtuin Family 8.47
bar=donor   line=cohort median 		8.34 72.9%
SIRT1 Sirtuin Family 8.53
bar=donor   line=cohort median 		8.72 23.5%
SIRT3 Sirtuin Family 7.67
bar=donor   line=cohort median 		7.49 81.9%
IGF1R Insulin/IGF-1 Signaling 10.77
bar=donor   line=cohort median 		10.21 97.0%
KLOTHO Anti-aging 2.68
bar=donor   line=cohort median 		2.51 74.0%
APOC3 Lipid Metabolism -2.12
bar=donor   line=cohort median 		-2.11 2.7%
IL6 Inflammation 1.04
bar=donor   line=cohort median 		1.16 18.5%
TERT Telomere Maintenance 1.75
bar=donor   line=cohort median 		1.51 87.3%
IRS2 Insulin/IGF-1 Signaling 9.50
bar=donor   line=cohort median 		9.81 22.4%
TP53 Tumor Suppression 9.35
bar=donor   line=cohort median 		8.92 98.0%
SHC1 Signal Transduction 9.57
bar=donor   line=cohort median 		9.35 92.3%
ACE Signal Transduction 4.96
bar=donor   line=cohort median 		4.64 80.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.7 0
2 MT-CO1 16.4 0
3 HLA-C 16.3 0
4 MT-RNR2 16.1 0
5 EEF1A1 16.0 0
6 CSF3R 16.0 0
7 B2M 16.0 0
8 HLA-E 15.9 0
9 HLA-B 15.9 0
10 CD74 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.3
bar=donor   line=cohort median 		14.2 14.2 3.0%
2 S100A9 14.5
bar=donor   line=cohort median 		15.4 15.5 2.7%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 60.0%
4 CXCL8 8.2
bar=donor   line=cohort median 		10.3 11.4 1.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.8
bar=donor   line=cohort median 		6.1 6.1 31.0%
6 FCGR3B 14.8
bar=donor   line=cohort median 		14.7 14.7 64.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.6
bar=donor   line=cohort median 		14.4 14.3 76.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.7
bar=donor   line=cohort median 		10.3 10.4 3.4%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 64.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.9
bar=donor   line=cohort median 		10.9 10.9 51.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.4
bar=donor   line=cohort median 		11.5 11.7 27.4%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 34.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 46.4%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.3 15.3 13.1%
18 MT-ND1 14.8
bar=donor   line=cohort median 		15.2 15.2 9.9%
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