Tissue-level analysis ยท GSE227358

Kidney RNA-seq profile

Kidney RNA-seq samples

A reproducible descriptive view of the deposited GSE227358 raw-count matrix: matrix-total CPM, sample composition, matrix-column sums, detected genes, high-expression ranking, and PCA. No differential-expression or causal claim is made.

Open dataset gene explorer โ†’ Open representative Kidney LACA view โ†’ Open GEO โ†—
Deposited matrix GSE227358 43,629 matrix rows
GSE227359 GSE227358
30selected samples
1represented tissue
12,866median genes at CPM โ‰ฅ 1
2.2Mmedian matrix column sum
Matrix overview

What is represented in this exact slice

Counts below refer only to the selected GSE227358 columns .

01

Intervention representation

Number of biological sample columns per group

AS703026 n = 4
Control n = 6
Enzastaurin n = 4
KU0063794 n = 4
GDC n = 4
AZD8055 n = 4
Ascorbyl n = 4
02

Matrix column sums

Per-sample total across all published gene rows

1.4M AS703026_kidney_1
1.1M AS703026_kidney_2
0.9M Control_kidney_1
1.8M Control_kidney_2
1.2M Enzastaurin_kidney_1
0.9M KU0063794_kidney_1
1.2M GDC_kidney_1
2.4M AZD8055_kidney_1
2.3M Ascorbyl_kidney_1
1.6M AZD8055_kidney_2
1.7M AZD8055_kidney_3
2.2M AZD8055_kidney_4
1.2M Control_kidney_3
1.3M Control_kidney_4
1.6M Control_kidney_5
3.8M Enzastaurin_kidney_2
3.4M Enzastaurin_kidney_3
3.3M Enzastaurin_kidney_4
2.6M Control_kidney_6
3.0M Ascorbyl_kidney_2
2.4M Ascorbyl_kidney_3
3.6M Ascorbyl_kidney_4
2.1M KU0063794_kidney_2
2.9M KU0063794_kidney_3
5.7M KU0063794_kidney_4
3.4M AS703026_kidney_3
2.7M AS703026_kidney_4
3.8M GDC_kidney_2
1.6M GDC_kidney_3
4.0M GDC_kidney_4

Range: 0.9Mโ€“5.7M counts. This is a matrix-column sum, not an independently reported sequencing depth.

Expression structure

Sample separation and dominant transcripts

Visual summaries retain replicate-level information and expose sample counts.

03

Principal component view

Exploratory structure in log2(CPM + 1)

AS703026 Control Enzastaurin KU0063794 GDC AZD8055 Ascorbyl

PCA of centered log2(matrix-total CPM + 1), using up to 500 highest-variance genes with nonzero matrix-total CPM in at least 20% of selected samples.

04

Top mean-expression genes

Ranked by mean matrix-total CPM

Kap 39,798.0 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000075014 29,355.8 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000064363 23,753.7 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000064370 19,871.0 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000064341 17,825.5 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000064339 14,809.3 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000064345 13,275.4 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000064368 12,242.5 CPM
30/30 samples at CPM โ‰ฅ 1
Aldob 7,441.4 CPM
30/30 samples at CPM โ‰ฅ 1
Gpx3 7,090.4 CPM
30/30 samples at CPM โ‰ฅ 1
ENSMUSG00000091028 6,473.6 CPM
30/30 samples at CPM โ‰ฅ 1
Acsm2 6,375.0 CPM
30/30 samples at CPM โ‰ฅ 1
Reproducible sample audit

Every selected matrix column

The table is the text equivalent for the sample-level visualizations above.

Sample Treatment Tissue Replicate Matrix column sum Genes at CPM โ‰ฅ 1
AS703026_kidney_1 AS703026 Kidney 1 1,413,342 12,850
AS703026_kidney_2 AS703026 Kidney 2 1,117,299 15,342
Control_kidney_1 Control Kidney 1 863,605 14,491
Control_kidney_2 Control Kidney 2 1,787,638 16,151
Enzastaurin_kidney_1 Enzastaurin Kidney 1 1,157,094 12,614
KU0063794_kidney_1 KU0063794 Kidney 1 894,034 17,190
GDC_kidney_1 GDC Kidney 1 1,199,109 15,205
AZD8055_kidney_1 AZD8055 Kidney 1 2,447,730 14,133
Ascorbyl_kidney_1 Ascorbyl Kidney 1 2,319,356 12,620
AZD8055_kidney_2 AZD8055 Kidney 2 1,553,748 14,643
AZD8055_kidney_3 AZD8055 Kidney 3 1,675,549 12,410
AZD8055_kidney_4 AZD8055 Kidney 4 2,177,744 12,882
Control_kidney_3 Control Kidney 3 1,187,020 13,913
Control_kidney_4 Control Kidney 4 1,334,020 12,839
Control_kidney_5 Control Kidney 5 1,644,042 14,131
Enzastaurin_kidney_2 Enzastaurin Kidney 2 3,828,065 12,665
Enzastaurin_kidney_3 Enzastaurin Kidney 3 3,447,364 12,486
Enzastaurin_kidney_4 Enzastaurin Kidney 4 3,257,442 12,378
Control_kidney_6 Control Kidney 6 2,559,118 12,473
Ascorbyl_kidney_2 Ascorbyl Kidney 2 2,961,707 12,973
Ascorbyl_kidney_3 Ascorbyl Kidney 3 2,416,030 12,582
Ascorbyl_kidney_4 Ascorbyl Kidney 4 3,569,053 19,103
KU0063794_kidney_2 KU0063794 Kidney 2 2,091,275 12,139
KU0063794_kidney_3 KU0063794 Kidney 3 2,889,635 12,734
KU0063794_kidney_4 KU0063794 Kidney 4 5,691,067 12,490
AS703026_kidney_3 AS703026 Kidney 3 3,393,796 16,635
AS703026_kidney_4 AS703026 Kidney 4 2,737,108 17,637
GDC_kidney_2 GDC Kidney 2 3,844,047 12,442
GDC_kidney_3 GDC Kidney 3 1,647,753 17,934
GDC_kidney_4 GDC Kidney 4 4,016,758 12,357
Method and provenance

How this page was calculated

Normalization

Matrix-total CPM

raw count / sum of all published matrix gene rows in the sample ร— 1,000,000. A gene is called detected at CPM โ‰ฅ 1.

Ranking

Descriptive mean expression

Top genes are ranked by mean CPM across the exact selected sample columns; no p-values are calculated.

Source integrity

GSE227358

SHA-256: d1afa2ea86b8f751023c385d8c0070cc390121d3cb5b7276b9697f9c44402bc4

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