Longevity & Aging
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Profiles
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Liver
Tissue-level analysis ยท GSE227358
Liver RNA-seq profile
Liver RNA-seq samples
A reproducible descriptive view of the deposited GSE227358 raw-count matrix:
matrix-total CPM, sample composition, matrix-column sums, detected genes, high-expression
ranking, and PCA. No differential-expression or causal claim is made.
Deposited matrix
GSE227358
43,629 matrix rows
12 selected samples
1 represented tissue
11,546 median genes at CPM โฅ 1
2.8M median matrix column sum
Interpretation boundary.
These are descriptive summaries of deposited raw counts normalized by the sum of all published
matrix rows in each sample. Matrix-total CPM is not a substitute for a full differential-expression
workflow, and the paper-wide 371-sample integration is not reconstructed here.
No liver control in this matrix.
GSE227358 contains liver treatment samples only; controls used by the publication came from
GSE131868. This page therefore does not calculate a liver fold change.
Matrix overview
What is represented in this exact slice
Counts below refer only to the selected GSE227358 columns
.
01
Intervention representation
Number of biological sample columns per group
02
Matrix column sums
Per-sample total across all published gene rows
Range: 1.1Mโ4.4M counts.
This is a matrix-column sum, not an independently reported sequencing depth.
Expression structure
Sample separation and dominant transcripts
Visual summaries retain replicate-level information and expose sample counts.
03
Principal component view
Exploratory structure in log2(CPM + 1)
PC1 ยท 35.2%
PC2 ยท 11.3%
PCA of centered log2(matrix-total CPM + 1), using up to 500 highest-variance genes with nonzero matrix-total CPM in at least 20% of selected samples.
04
Top mean-expression genes
Ranked by mean matrix-total CPM
Apoe
26,363.8 CPM
12/12 samples at CPM โฅ 1
Alb
20,374.3 CPM
12/12 samples at CPM โฅ 1
Ttr
19,378.1 CPM
12/12 samples at CPM โฅ 1
Serpina3k
12,953.5 CPM
12/12 samples at CPM โฅ 1
ENSMUSG00000064363
12,277.4 CPM
12/12 samples at CPM โฅ 1
Ahsg
11,649.1 CPM
12/12 samples at CPM โฅ 1
Apoa1
11,300.9 CPM
12/12 samples at CPM โฅ 1
Mup3
10,802.2 CPM
12/12 samples at CPM โฅ 1
Mup11
10,769.6 CPM
12/12 samples at CPM โฅ 1
Hpx
10,469.7 CPM
12/12 samples at CPM โฅ 1
Trf
10,440.9 CPM
12/12 samples at CPM โฅ 1
Apoa2
10,145.3 CPM
12/12 samples at CPM โฅ 1
Reproducible sample audit
Every selected matrix column
The table is the text equivalent for the sample-level visualizations above.
Sample
Treatment
Tissue
Replicate
Matrix column sum
Genes at CPM โฅ 1
AS703026_liver_1
AS703026
Liver
1
2,486,098
11,815
AS703026_liver_2
AS703026
Liver
2
1,084,591
11,170
Enzastaurin_liver_1
Enzastaurin
Liver
1
1,940,538
11,521
Enzastaurin_liver_2
Enzastaurin
Liver
2
4,361,115
11,542
GDC_liver_1
GDC
Liver
1
2,501,384
11,561
AS703026_liver_3
AS703026
Liver
3
3,671,146
11,788
AS703026_liver_4
AS703026
Liver
4
2,850,188
11,990
Enzastaurin_liver_3
Enzastaurin
Liver
3
2,318,594
11,537
GDC_liver_2
GDC
Liver
2
3,465,666
11,622
GDC_liver_3
GDC
Liver
3
3,098,780
11,321
GDC_liver_4
GDC
Liver
4
2,735,347
11,551
Enzastaurin_liver_4
Enzastaurin
Liver
4
3,357,263
11,208
Method and provenance
How this page was calculated
Normalization
Matrix-total CPM
raw count / sum of all published matrix gene rows in the sample ร 1,000,000. A gene is called detected at CPM โฅ 1.
Ranking
Descriptive mean expression
Top genes are ranked by mean CPM across the exact selected sample columns; no p-values are calculated.
Source integrity
GSE227358
SHA-256: d1afa2ea86b8f751023c385d8c0070cc390121d3cb5b7276b9697f9c44402bc4