TFs Analyzed
73
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP025
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=2,400,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
327
Thresholded Pearson associations
Top TF Association Counts
AHR
10 associations
GATA1
7 associations
GATA2
24 associations
GATA3
12 associations
LEF1
57 associations
NFKB1
8 associations
PAX6
56 associations
RUNX1
46 associations
SOX9
43 associations
TCF7
24 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
800
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
8
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| VIT | 13.774 | 5.207 | 0 | 0 | 0.5167 | 0.0381 | Astrocytes |
| FGFRL1 | 20.3686 | 4.9727 | 0 | 0 | 0.79 | 0.1124 | Astrocytes |
| ETNPPL | 11.5959 | 4.8538 | 0 | 0 | 0.44 | 0.0329 | Astrocytes |
| PRDM16 | 22.2822 | 4.6859 | 0 | 0 | 0.9267 | 0.1948 | Astrocytes |
| NHSL1 | 21.5296 | 4.6635 | 0 | 0 | 0.8433 | 0.2467 | Astrocytes |
| SLC1A2 | 26.5926 | 4.6416 | 0 | 0 | 0.9967 | 0.7114 | Astrocytes |
| SNTB1 | 13.1906 | 4.5456 | 0 | 0 | 0.51 | 0.0529 | Astrocytes |
| LRIG1 | 21.0422 | 4.3401 | 0 | 0 | 0.8433 | 0.2129 | Astrocytes |
| RGS17 | 19.4988 | 4.245 | 0 | 0 | 0.78 | 0.2538 | Astrocytes |
| FARP1 | 20.8776 | 4.1847 | 0 | 0 | 0.84 | 0.2619 | Astrocytes |
| EGFL7 | 18.6497 | 7.3803 | 0 | 0 | 0.6733 | 0.0195 | Endothelial cells |
| CDH5 | 12.7851 | 6.8415 | 0 | 0 | 0.4633 | 0.0114 | Endothelial cells |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
7
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
14
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0524 | 19.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocyte progenitor cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.5816 | 88.6667 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0636 | 20.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0444 | 9.6667 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Microglia | Kinase inhibitor | CML / GIST | 5 | 5 | 0.2398 | 45.3333 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.1034 | 24 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Ependymal cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0742 | 18 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Endothelial cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0749 | 15.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Methotrexate | Excitatory neurons | Antimetabolite | RA / Cancer | 3 | 3 | 0.0516 | 11.6667 | 0 | DHFR,TYMS,ATIC |
| Methotrexate | Oligodendrocyte progenitor cells | Antimetabolite | RA / Cancer | 3 | 3 | 0.123 | 18.6667 | 0 | DHFR,TYMS,ATIC |
| Methotrexate | Inhibitory neurons | Antimetabolite | RA / Cancer | 3 | 3 | 0.1044 | 20.6667 | 0 | DHFR,TYMS,ATIC |
| Methotrexate | Oligodendrocytes | Antimetabolite | RA / Cancer | 3 | 3 | 0.0491 | 7 | 0 | DHFR,TYMS,ATIC |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP025
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP025_summary.json | Summary (JSON) | ๐ฅ Download |