TFs Analyzed
5
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP053
Published legacy analysis modules for the selected page.
๐ Species Level
No validated Atlas analysis release is published for this page.
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=46,321,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
37
Thresholded Pearson associations
Top TF Association Counts
EGR1
1 associations
MYC
18 associations
SOX2
18 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
27,043
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
300
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| TMEM249 | 29.0399 | 8.7418 | 0 | 0 | 1 | 0.1765 | B:Animal_pole |
| SH2B2 | 29.0921 | 7.9407 | 0 | 0 | 1 | 0.1681 | B:Animal_pole |
| NBAS | 26.3511 | 5.456 | 0 | 0 | 1 | 0.5408 | B:Animal_pole |
| MIIP | 20.3402 | 5.0091 | 0 | 0 | 0.7667 | 0.1407 | B:Animal_pole |
| MMP25 | 25.3194 | 4.9907 | 0 | 0 | 1 | 0.4853 | B:Animal_pole |
| GPLD1 | 24.4232 | 4.9875 | 0 | 0 | 0.9533 | 0.35 | B:Animal_pole |
| COMMD7 | 18.093 | 4.7733 | 0 | 0 | 0.6833 | 0.1116 | B:Animal_pole |
| ERI3 | 3.0994 | 4.735 | 0.0019 | 0.0166 | 0.11 | 0.007 | B:Animal_pole |
| SLU7 | 24.4916 | 4.6809 | 0 | 0 | 0.93 | 0.3561 | B:Animal_pole |
| PWWP2B | 5.1318 | 4.1089 | 0 | 0 | 0.19 | 0.0217 | B:Animal_pole |
| TMEM249 | 29.324 | 8.8907 | 0 | 0 | 1 | 0.1765 | B:Animal_vegetal_border |
| SH2B2 | 29.069 | 7.92 | 0 | 0 | 1 | 0.1681 | B:Animal_vegetal_border |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
11
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
302
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
98
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
3
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
302
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Methotrexate | N2:Epithelial_ectoderm_N2 | Antimetabolite | RA / Cancer | 2 | 3 | 0.0271 | 2.3333 | 0 | TYMS,ATIC |
| Methotrexate | N2:Immature_sensory_neurons_N2 | Antimetabolite | RA / Cancer | 2 | 3 | 0.0112 | 1.6667 | 0 | TYMS,ATIC |
| Methotrexate | N2:Epithelial_ectoderm_anterior_N2 | Antimetabolite | RA / Cancer | 2 | 3 | 0.0309 | 2.6667 | 0 | TYMS,ATIC |
| Methotrexate | N2:Epithelial_ectoderm_near_neural_roof_posterior_1 | Antimetabolite | RA / Cancer | 2 | 3 | 0.0317 | 3.3333 | 0 | TYMS,ATIC |
| Methotrexate | N2:Pre_oral_pit_12 | Antimetabolite | RA / Cancer | 2 | 3 | 0.2402 | 23.6667 | 0 | TYMS,ATIC |
| Methotrexate | N2:Epithelial_ectoderm_near_neural_roof_middle_5 | Antimetabolite | RA / Cancer | 2 | 3 | 0.0164 | 2 | 0 | TYMS,ATIC |
| Methotrexate | N2:Pharyngeal_endoderm_gills_endostyle_8 | Antimetabolite | RA / Cancer | 2 | 3 | 0.2331 | 22.6667 | 0 | TYMS,ATIC |
| Methotrexate | N2:Prechordal_plate_7 | Antimetabolite | RA / Cancer | 2 | 3 | 0.16 | 15 | 0 | TYMS,ATIC |
| Methotrexate | N2:Somite_paraxial_mature_non-first_11 | Antimetabolite | RA / Cancer | 2 | 3 | 0.1742 | 19.3333 | 0 | TYMS,ATIC |
| Methotrexate | N2:Club_shaped_gland_10 | Antimetabolite | RA / Cancer | 2 | 3 | 0.1822 | 17.6667 | 0 | TYMS,ATIC |
| Methotrexate | N2:Tailbud_9 | Antimetabolite | RA / Cancer | 2 | 3 | 0.109 | 8.6667 | 0 | TYMS,ATIC |
| Methotrexate | N2:Notochord_near_posterior_13 | Antimetabolite | RA / Cancer | 2 | 3 | 0.1555 | 16.3333 | 0 | TYMS,ATIC |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP053
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP053_summary.json | Summary (JSON) | ๐ฅ Download |