Exploratory Modules Available

Analysis Results SP121

Published legacy analysis modules for the selected page.

Species: SP121

Generated: 2026-08-07 23:48

Modules: 9

📊 Species Level

Validated exploratory / stratified sample. Artifact and provenance checks passed for the linked advanced-module package. These tabs use a deterministic tissue x cell-type stratified sample (n=44,523, seed=12120260808) and are descriptive cell-level analyses, not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.

📡

Cell Interactions

🧬

1,511

TF-Target Pairs

📊

10,700

Significant DEGs

🎯

96,391

GO Terms

🛤️

16,951

KEGG Pathways

🔗

Co-exp Modules

⚗️

Metab. Pathways

🏥

Disease Links

💊

Drugs Matched

📡 Cell Communication Not computed 🧬 TF Associations Exploratory 🔗 Co-expression Exploratory 🔀 Trajectory Not computed 📊 Marker Ranking Exploratory 🎯 GO / KEGG Exploratory 🧪 ToppGene Exploratory 🔠 Motif Exploratory ⚗️ Metabolism Exploratory 🏥 Disease Exploratory 💊 Drug Analysis Exploratory 📄 Full Report

🧬

Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference

🎛️

TFs Analyzed

Transcription factors profiled

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TF-Target Pairs

1,511

Thresholded Pearson associations

Top TF Association Counts

CEBPB 140 associations

EGR1 132 associations

FOS 132 associations

IRF1 76 associations

JUN 105 associations

MYC 64 associations

NFKB1 110 associations

RB1 70 associations

RUNX1 95 associations

STAT3 89 associations

TF Activity Heatmap

Z-score normalized TF expression across cell populations.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

Exploratory TF-Target Association Network

Pearson TF-target associations in the stratified sample; not a causal regulatory network.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

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Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only

📦

Modules Identified

Co-expression gene modules

🧬

Genes Analyzed

2,000

Highly variable genes

Module Dendrogram

Hierarchical clustering of expression correlations in the stratified sample.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

Module-Cell Type Association

Module eigengene activity across cell types.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

📊

Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference

📈

Ranked Marker Rows

10,700

Cell-level descriptive thresholds; no independent donor replicates

🏷️

Cell Types Compared

107

Cell populations analyzed

Marker Ranking Volcano Plot

Cell-level descriptive marker ranking; not donor-level differential inference.

Marker Gene Heatmap

Z-score normalized expression of top marker genes per cell type.

📋 Top Marker Genes

📥 Top Markers 📥 All Significant DEGs 📥 Full DEG Results

names	scores	logfoldchanges	pct_nz_group	pct_nz_reference	cell_type
PRSS1	34.3522	12.5075	0.896	0.0226	Acinar cells
CLPS	34.3674	12.3186	0.896	0.0222	Acinar cells
PNLIP	34.3514	12.0676	0.896	0.0204	Acinar cells
CPA1	34.3469	11.8345	0.896	0.0238	Acinar cells
CTRB1	34.3659	11.7796	0.896	0.0227	Acinar cells
PRSS2	34.353	11.7668	0.896	0.0234	Acinar cells
SYCN	34.3752	11.2065	0.896	0.0186	Acinar cells
CTRC	34.286	11.1581	0.894	0.0248	Acinar cells
CPB1	34.2748	11.1133	0.896	0.0401	Acinar cells
REG1A	34.3151	10.6958	0.896	0.0303	Acinar cells
DCLK1	35.8437	6.3802	0.968	0.1357	Adipocyte progenitor cells
EBF1	35.7013	5.96	0.988	0.1745	Adipocyte progenitor cells

Showing top 12 rows

🎯

Functional EnrichmentFrozen GO / KEGG ORA on descriptive marker signatures

🧬

GO Terms

96,391

Enriched Gene Ontology terms

🛤️

KEGG Pathways

16,951

Enriched KEGG pathways

GO Enrichment

Top enriched Gene Ontology terms across cell types.

🔍 Full Size

KEGG Pathway Enrichment

Dot size: gene count. Color: significance.

🔍 Full Size

📥 GO Results 📥 KEGG Results

🧪

ToppGene AnalysisToppGene API enrichment on descriptive marker signatures

🏷️

Cell Types Analyzed

107

Gene lists submitted

✅

Total Enrichments

180,015

Across all categories

ToppGene Functional Summary

Category distribution and top enriched functional terms.

📥 ToppGene Results

🔠

Motif EnrichmentcisTarget gene-set enrichment; not a full pySCENIC GRN

🔬

Unique Enriched Motifs

2075

Unique motif IDs with NES ≥ 3

✅

Significant Enrichments

22788

Motif-signature-context rows with NES ≥ 3

TF Motif Enrichment Heatmap

Motif enrichment scores across cell types.

📥 Motif Enrichment

⚗️

Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only

🧪

Pathways Scored

Metabolic pathway gene sets tested

✅

Pathways Detected

Pathways with genes expressed in data

🏷️

Cell Types Analyzed

107

Cell populations scored

Top Metabolic Pathways

Oxidative Phosphorylation Glycolysis Pentose Phosphate TCA Cycle Glutamine Metabolism

Metabolic Pathway Heatmap

Curated metabolic gene-set expression scores across sampled cell types.

🔍 Full Size

Top Metabolic Activities

Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.

🔍 Full Size

📥 Metabolism Scores

🏥

Disease AssociationCurated disease-gene set overlap; descriptive only

🔬

Diseases Tested

Disease categories analyzed

✅

Significant Associations

Cell type-disease links (adj. p < 0.05)

Top Associated Diseases

Systemic lupus erythematosus Multiple sclerosis Autism spectrum disorder Cardiovascular disease Type 2 diabetes

Disease Association Heatmap

Curated disease-gene set overlap across sampled cell types; descriptive only.

Top Disease Associations

Dot size: overlap genes. Color: significance.

📥 Disease Enrichment Data

💊

Drug Target AnalysisCurated drug-target expression matching; descriptive only

💊

Drugs Screened

Drug compounds evaluated

🎯

Drugs with Targets

Drugs with target genes detected in data

🏷️

Cell Types Analyzed

107

Cell populations scored

Top Associated Drugs

Cyclosporine Dexamethasone Ruxolitinib Erlotinib Tocilizumab

Drug Target Expression Heatmap

Curated drug-target expression scores across sampled cell types; descriptive only.

🔍 Full Size

Top Drug–Cell Type Associations

Dot size: % cells expressing targets. Color: number of targets detected.

🔍 Full Size

📋 Drug–Cell Type Scores

📥 Drug Scores

drug	cell_type	category	indication	targets_detected	targets_total	mean_target_expr	pct_cells_expressing	deg_overlap	target_genes
Imatinib	Smooth muscle cells	Kinase inhibitor	CML / GIST	5	5	0.3475	80.6	1	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Natural killer T cells	Kinase inhibitor	CML / GIST	5	5	0.0848	30.2	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	T cells	Kinase inhibitor	CML / GIST	5	5	0.0595	21.4	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Urothelial cells	Kinase inhibitor	CML / GIST	5	5	0.0799	44.6	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Macrophages	Kinase inhibitor	CML / GIST	5	5	0.2614	70.2	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Monocytes	Kinase inhibitor	CML / GIST	5	5	0.0882	34.8	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Plasma B cells	Kinase inhibitor	CML / GIST	5	5	0.0343	23.6	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Natural killer cells	Kinase inhibitor	CML / GIST	5	5	0.1183	41.8	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	B cells	Kinase inhibitor	CML / GIST	5	5	0.0525	21.2	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Squamous cells	Kinase inhibitor	CML / GIST	5	5	0.023	12.8	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Basal cells	Kinase inhibitor	CML / GIST	5	5	0.0783	33.8	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R
Imatinib	Endothelial cells	Kinase inhibitor	CML / GIST	5	5	0.109	40.6	0	ABL1,KIT,PDGFRA,PDGFRB,CSF1R

Showing top 12 rows · Download full table above

📄

Exploratory Analysis FilesValidated module artifacts and individual downloads

📦

Exploratory Result Files

Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.

🔗

Share Results

Use this permanent link to share these analysis results:


                analysis.php?SP_ID=SP121

📁 Available Result Files

Analysis	File	Type	Action
TF Associations	grn_tf_heatmap.png	Figure (PNG)	🔍 View
TF Associations	grn_network.png	Figure (PNG)	🔍 View
TF Associations	grn_tf_activity.csv	Data (CSV)	📥 Download
TF Associations	grn_tf_targets.csv	Data (CSV)	📥 Download
Co-expression	coexp_dendrogram.png	Figure (PNG)	🔍 View
Co-expression	coexp_module_heatmap.png	Figure (PNG)	🔍 View
Co-expression	coexp_modules.csv	Data (CSV)	📥 Download
Co-expression	coexp_eigengenes.csv	Data (CSV)	📥 Download
Marker Ranking	deg_volcano.png	Figure (PNG)	🔍 View
Marker Ranking	deg_marker_heatmap.png	Figure (PNG)	🔍 View
Marker Ranking	deg_top_markers.csv	Data (CSV)	📥 Download
Marker Ranking	deg_significant.csv	Data (CSV)	📥 Download
Marker Ranking	deg_all_results.csv	Data (CSV)	📥 Download
GO / KEGG	enrichment_go_barplot.png	Figure (PNG)	🔍 View
GO / KEGG	enrichment_kegg_dotplot.png	Figure (PNG)	🔍 View
GO / KEGG	enrichment_go.csv	Data (CSV)	📥 Download
GO / KEGG	enrichment_kegg.csv	Data (CSV)	📥 Download
ToppGene	toppgene_summary.png	Figure (PNG)	🔍 View
ToppGene	toppgene_results.csv	Data (CSV)	📥 Download
Motif	motif_heatmap.png	Figure (PNG)	🔍 View
Motif	motif_enrichment.csv	Data (CSV)	📥 Download
Metabolism	metabolism_heatmap.png	Figure (PNG)	🔍 View
Metabolism	metabolism_dotplot.png	Figure (PNG)	🔍 View
Metabolism	metabolism_scores.csv	Data (CSV)	📥 Download
Disease	disease_heatmap.png	Figure (PNG)	🔍 View
Disease	disease_dotplot.png	Figure (PNG)	🔍 View
Disease	disease_enrichment.csv	Data (CSV)	📥 Download
Drug Analysis	drug_heatmap.png	Figure (PNG)	🔍 View
Drug Analysis	drug_dotplot.png	Figure (PNG)	🔍 View
Drug Analysis	drug_scores.csv	Data (CSV)	📥 Download
Report	SP121_summary.json	Summary (JSON)	📥 Download