TFs Analyzed
34
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP1784
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=1,476,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
310
Thresholded Pearson associations
Top TF Association Counts
AR
41 associations
E2F1
17 associations
EGR1
27 associations
ETS1
14 associations
LEF1
9 associations
MAFK
10 associations
NR3C1
17 associations
SOX2
48 associations
SREBF1
30 associations
TFEB
29 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
548
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
6
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| OC90 | 8.6963 | 8.3376 | 0 | 0 | 0.3267 | 0.0026 | Astrocytes |
| HHLA1 | 15.9742 | 8.0489 | 0 | 0 | 0.6033 | 0.0111 | Astrocytes |
| PREX1 | 20.298 | 5.6005 | 0 | 0 | 0.8467 | 0.1122 | Astrocytes |
| GRIN3B | 17.9105 | 5.0868 | 0 | 0 | 0.7567 | 0.1173 | Astrocytes |
| COBL | 17.5339 | 5.0017 | 0 | 0 | 0.7433 | 0.1003 | Astrocytes |
| AFAP1L2 | 7.4262 | 4.9176 | 0 | 0 | 0.2933 | 0.0136 | Astrocytes |
| GPC1 | 17.8914 | 4.7612 | 0 | 0 | 0.82 | 0.1922 | Astrocytes |
| NPAS3 | 23.5675 | 4.7457 | 0 | 0 | 1 | 0.5748 | Astrocytes |
| FGFR2 | 20.2254 | 4.7278 | 0 | 0 | 0.9733 | 0.3257 | Astrocytes |
| WDR73 | 17.8472 | 4.6042 | 0 | 0 | 0.8433 | 0.1837 | Astrocytes |
| EPHA6 | 14.0242 | 4.5344 | 0 | 0 | 0.59 | 0.0765 | Excitatory neurons |
| EPHA5 | 9.2098 | 4.0965 | 0 | 0 | 0.3833 | 0.0408 | Excitatory neurons |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
6
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
3
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
9
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
6
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 3 | 5 | 0.5242 | 44.3333 | 1 | ABL1,PDGFRA,PDGFRB |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 3 | 5 | 0.083 | 8.6667 | 0 | ABL1,PDGFRA,PDGFRB |
| Imatinib | Radial glial cells | Kinase inhibitor | CML / GIST | 3 | 5 | 0.4244 | 31.6667 | 0 | ABL1,PDGFRA,PDGFRB |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 3 | 5 | 0.1889 | 16.1765 | 0 | ABL1,PDGFRA,PDGFRB |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 3 | 5 | 0.1409 | 16 | 0 | ABL1,PDGFRA,PDGFRB |
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 3 | 5 | 1.0601 | 66.6667 | 1 | ABL1,PDGFRA,PDGFRB |
| Trastuzumab | Astrocytes | mAb | Breast cancer | 1 | 1 | 0.2745 | 9.3333 | 0 | ERBB2 |
| Trastuzumab | Inhibitory neurons | mAb | Breast cancer | 1 | 1 | 0.017 | 0.6667 | 0 | ERBB2 |
| Trastuzumab | Radial glial cells | mAb | Breast cancer | 1 | 1 | 0.2057 | 6 | 0 | ERBB2 |
| Trastuzumab | Oligodendrocytes | mAb | Breast cancer | 1 | 1 | 0.2212 | 6.8627 | 0 | ERBB2 |
| Trastuzumab | Excitatory neurons | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
| Trastuzumab | Fibroblasts | mAb | Breast cancer | 1 | 1 | 0.0739 | 2.7778 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP1784
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP1784_summary.json | Summary (JSON) | ๐ฅ Download |