Analysis Complete

Analysis Results sys05

Published legacy analysis modules for the selected page.

Species: SP239

System: sys05

Generated: 2026-08-07 23:48

Modules: 5

📊 System Level

📡

27,461

Cell Interactions

🧬

1,039

TF-Target Pairs

📊

3,450

Significant DEGs

🎯

315

GO Terms

🛤️

280

KEGG Pathways

🔗

Co-exp Modules

⚗️

—

Metab. Pathways

🏥

Disease Links

💊

—

Drugs Matched

📡 Cell Communication ✓ 🧬 GRN Analysis ✓ 🔗 Co-expression ✓ 🔀 Trajectory Not computed 📊 DEG Analysis ✓ 🎯 GO / KEGG Not computed 🧪 ToppGene Not computed 🔠 Motif Not computed ⚗️ Metabolism Not computed 🏥 Disease ✓ 💊 Drug Analysis Not computed 📄 Full Report

📡

Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB

🔢

Total Interactions

27,461

Significant ligand-receptor pairs

🛤️

Signaling Pathways

Unique pathways detected

📤

Top Sender

Fibroblasts

Most active signaling cell type

📥

Top Receiver

Innate lymphoid cells

Most active receiving cell type

Communication Heatmap

Overall interaction strength between cell types. Rows = sender, columns = receiver.

🔍 Full Size

Communication Network

Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.

🔍 Full Size

Signaling Pathway Activity

Top signaling pathways ranked by total communication score.

🔍 Full Size

📋 Top Ligand-Receptor Interactions

📥 All Interactions 📥 Pathway Summary

source	target	ligand	receptor	pathway	ligand_expr	receptor_expr	score
Enterocytes	Enterocytes	TGFB1	TGFBR1	TGFb	0.0047	0.05	0.0002
Enterocytes	Cycling B cells	TGFB1	TGFBR1	TGFb	0.0047	0.2127	0.001
Enterocytes	Innate lymphoid cells	TGFB1	TGFBR1	TGFb	0.0047	0.3643	0.0017
Enterocytes	Endothelial cells	TGFB1	TGFBR1	TGFb	0.0047	0.1252	0.0006
Enterocytes	Macrophages	TGFB1	TGFBR1	TGFb	0.0047	0.2425	0.0011
Enterocytes	Fibroblasts	TGFB1	TGFBR1	TGFb	0.0047	0.8086	0.0038
Enterocytes	B cells	TGFB1	TGFBR1	TGFb	0.0047	0.2357	0.0011
Enterocytes	Smooth muscle cells	TGFB1	TGFBR1	TGFb	0.0047	0.2383	0.0011
Enterocytes	CD4+ T cells	TGFB1	TGFBR1	TGFb	0.0047	0.2262	0.0011
Enterocytes	Pericytes	TGFB1	TGFBR1	TGFb	0.0047	0.2926	0.0014
Enterocytes	Enteric glial cells	TGFB1	TGFBR1	TGFb	0.0047	0.3066	0.0014
Enterocytes	CD8+ T cells	TGFB1	TGFBR1	TGFb	0.0047	0.2112	0.001

Showing top 12 rows · Download full table above

🧬

Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)

🎛️

TFs Analyzed

Transcription factors profiled

🔗

TF-Target Pairs

1,039

Significant regulatory relationships

Top Regulatory TFs

FOS 154 targets

JUN 134 targets

HNF4A 111 targets

EGR1 66 targets

CEBPB 56 targets

RUNX1 55 targets

IRF1 55 targets

FOXA1 47 targets

GATA4 41 targets

MYC 36 targets

TF Activity Heatmap

Z-score normalized TF expression across cell populations.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

Gene Regulatory Network

Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

🔗

Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)

📦

Modules Identified

Co-expression gene modules

🧬

Genes Analyzed

2,000

Highly variable genes

Module Dendrogram

Hierarchical clustering of co-expression modules based on topological overlap.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

Module-Cell Type Association

Module eigengene activity across cell types.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

📊

Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)

📈

Significant DEGs

3,450

Genes passing adj. p < 0.05 & |log2FC| > 0.5

🏷️

Cell Types Compared

Cell populations analyzed

Volcano Plot

Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.

Marker Gene Heatmap

Z-score normalized expression of top marker genes per cell type.

📋 Top Marker Genes

📥 Top Markers 📥 All Significant DEGs 📥 Full DEG Results

names	scores	logfoldchanges	pct_nz_group	pct_nz_reference	cell_type
CELA1	157.2526	6.9719	0.9478	0.1175	Acinar cells
CPA2	159.3551	6.7239	0.9587	0.1063	Acinar cells
CPB1	153.7103	6.4722	0.935	0.1045	Acinar cells
CEL	149.6516	6.301	0.8989	0.104	Acinar cells
CTRL	149.3951	6.2087	0.9012	0.0968	Acinar cells
CPA1	138.8981	5.9054	0.8397	0.0912	Acinar cells
RBPJL	139.9447	5.8205	0.847	0.0928	Acinar cells
PDIA2	152.8274	5.6493	0.9353	0.2114	Acinar cells
CPA3	129.5645	5.548	0.79	0.0883	Acinar cells
PNLIPRP2	120.0605	5.4035	0.7234	0.0759	Acinar cells
CD74	175.1012	8.3374	0.9996	0.2103	B cells
MS4A1	159.5557	7.6397	0.9108	0.0356	B cells

Showing top 12 rows

🏥

Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)

🔬

Diseases Tested

Disease categories analyzed

✅

Significant Associations

Cell type-disease links (adj. p < 0.05)

Top Associated Diseases

Systemic lupus erythematosus Alzheimer disease Alzheimer disease Multiple sclerosis Systemic lupus erythematosus

Disease Association Heatmap

-Log10(P-value) of disease gene enrichment per cell type.

Top Disease Associations

Dot size: overlap genes. Color: significance.

📥 Disease Enrichment Data

📄

Full Analysis ReportComprehensive Summary & Downloads

📊

Interactive HTML Report

Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.

📄 Open Report

📦

Download All Results

Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.

📥 Download ZIP

🔗

Share Results

Use this permanent link to share these analysis results:


                analysis.php?SP_ID=SP239&sysID=sys05

📁 Available Result Files

Analysis	File	Type	Action
Cell Communication	cellchat_heatmap.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_network.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_pathway_dotplot.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_interactions.csv	Data (CSV)	📥 Download
Cell Communication	cellchat_pathway_summary.csv	Data (CSV)	📥 Download
GRN Analysis	grn_tf_heatmap.png	Figure (PNG)	🔍 View
GRN Analysis	grn_network.png	Figure (PNG)	🔍 View
GRN Analysis	grn_tf_activity.csv	Data (CSV)	📥 Download
GRN Analysis	grn_tf_targets.csv	Data (CSV)	📥 Download
Co-expression	coexp_dendrogram.png	Figure (PNG)	🔍 View
Co-expression	coexp_module_heatmap.png	Figure (PNG)	🔍 View
Co-expression	coexp_modules.csv	Data (CSV)	📥 Download
Co-expression	coexp_eigengenes.csv	Data (CSV)	📥 Download
DEG Analysis	deg_volcano.png	Figure (PNG)	🔍 View
DEG Analysis	deg_marker_heatmap.png	Figure (PNG)	🔍 View
DEG Analysis	deg_top_markers.csv	Data (CSV)	📥 Download
DEG Analysis	deg_significant.csv	Data (CSV)	📥 Download
DEG Analysis	deg_all_results.csv	Data (CSV)	📥 Download
Disease	disease_heatmap.png	Figure (PNG)	🔍 View
Disease	disease_dotplot.png	Figure (PNG)	🔍 View
Disease	disease_enrichment.csv	Data (CSV)	📥 Download
Report	sys05_analysis_report.html	Report (HTML)	📄 Open
Report	sys05_summary.json	Summary (JSON)	📥 Download