Analysis Complete

Analysis Results sys01tis16

Published legacy analysis modules for the selected page.

Species: SP239

Tissue: sys01tis16

Generated: 2026-08-07 23:48

Modules: 5

📊 Tissue Level

📡

1,073

Cell Interactions

🧬

TF-Target Pairs

📊

739

Significant DEGs

🎯

GO Terms

🛤️

KEGG Pathways

🔗

Co-exp Modules

⚗️

—

Metab. Pathways

🏥

Disease Links

💊

—

Drugs Matched

📡 Cell Communication ✓ 🧬 GRN Analysis ✓ 🔗 Co-expression ✓ 🔀 Trajectory Not computed 📊 DEG Analysis ✓ 🎯 GO / KEGG Not computed 🧪 ToppGene Not computed 🔠 Motif Not computed ⚗️ Metabolism Not computed 🏥 Disease ✓ 💊 Drug Analysis Not computed 📄 Full Report

📡

Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB

🔢

Total Interactions

1,073

Significant ligand-receptor pairs

🛤️

Signaling Pathways

Unique pathways detected

📤

Top Sender

Purkinje cells

Most active signaling cell type

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Top Receiver

Inhibitory neurons

Most active receiving cell type

Communication Heatmap

Overall interaction strength between cell types. Rows = sender, columns = receiver.

🔍 Full Size

Communication Network

Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.

🔍 Full Size

Signaling Pathway Activity

Top signaling pathways ranked by total communication score.

🔍 Full Size

📋 Top Ligand-Receptor Interactions

📥 All Interactions 📥 Pathway Summary

source	target	ligand	receptor	pathway	ligand_expr	receptor_expr	score
Excitatory neurons	Excitatory neurons	TGFB1	TGFBR1	TGFb	0.0037	0.1083	0.0004
Excitatory neurons	Oligodendrocytes	TGFB1	TGFBR1	TGFb	0.0037	0.1054	0.0004
Excitatory neurons	Microglia	TGFB1	TGFBR1	TGFb	0.0037	0.104	0.0004
Excitatory neurons	Inhibitory neurons	TGFB1	TGFBR1	TGFb	0.0037	0.1035	0.0004
Excitatory neurons	Astrocytes	TGFB1	TGFBR1	TGFb	0.0037	0.1063	0.0004
Excitatory neurons	Oligodendrocyte progenitor cells	TGFB1	TGFBR1	TGFb	0.0037	0.1974	0.0007
Excitatory neurons	Choroid plexus	TGFB1	TGFBR1	TGFb	0.0037	0.0672	0.0002
Excitatory neurons	Purkinje cells	TGFB1	TGFBR1	TGFb	0.0037	0.1342	0.0005
Oligodendrocytes	Excitatory neurons	TGFB1	TGFBR1	TGFb	0.0019	0.1083	0.0002
Oligodendrocytes	Oligodendrocytes	TGFB1	TGFBR1	TGFb	0.0019	0.1054	0.0002
Oligodendrocytes	Microglia	TGFB1	TGFBR1	TGFb	0.0019	0.104	0.0002
Oligodendrocytes	Inhibitory neurons	TGFB1	TGFBR1	TGFb	0.0019	0.1035	0.0002

Showing top 12 rows · Download full table above

🧬

Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)

🎛️

TFs Analyzed

Transcription factors profiled

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TF-Target Pairs

Significant regulatory relationships

Top Regulatory TFs

RUNX1 8 targets

FOXA2 5 targets

SOX2 2 targets

FOS 1 targets

STAT3 1 targets

PAX6 1 targets

TCF7 1 targets

TF Activity Heatmap

Z-score normalized TF expression across cell populations.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

Gene Regulatory Network

Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

🔗

Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)

📦

Modules Identified

Co-expression gene modules

🧬

Genes Analyzed

2,000

Highly variable genes

Module Dendrogram

Hierarchical clustering of co-expression modules based on topological overlap.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

Module-Cell Type Association

Module eigengene activity across cell types.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

📊

Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)

📈

Significant DEGs

739

Genes passing adj. p < 0.05 & |log2FC| > 0.5

🏷️

Cell Types Compared

Cell populations analyzed

Volcano Plot

Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.

Marker Gene Heatmap

Z-score normalized expression of top marker genes per cell type.

📋 Top Marker Genes

📥 Top Markers 📥 All Significant DEGs 📥 Full DEG Results

names	scores	logfoldchanges	pvals	pvals_adj	pct_nz_group	pct_nz_reference	cell_type
MLC1	37.8273	7.4747	0	0	0.5425	0.0113	Astrocytes
SLC1A3	54.3206	7.1147	0	0	0.7847	0.042	Astrocytes
GDPD2	29.1013	6.847	0	0	0.4196	0.0106	Astrocytes
F5	29.431	6.6192	0	0	0.4282	0.0183	Astrocytes
ATP13A4	16.7846	6.6032	0	0	0.2423	0.0055	Astrocytes
RFX4	19.1472	6.1195	0	0	0.2778	0.0079	Astrocytes
IL33	13.3556	5.9513	0	0	0.1946	0.0063	Astrocytes
ARHGEF26	36.0913	5.6653	0	0	0.5333	0.0413	Astrocytes
ATP1A2	29.2751	5.555	0	0	0.4323	0.0238	Astrocytes
SPARCL1	56.3419	5.3734	0	0	0.8444	0.1699	Astrocytes
SLC5A5	6.081	7.6673	0	0	0.2538	0.0039	Choroid plexus
CATIP	3.405	6.8285	0.0007	0.0122	0.1421	0.0018	Choroid plexus

Showing top 12 rows

🏥

Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)

🔬

Diseases Tested

Disease categories analyzed

✅

Significant Associations

Cell type-disease links (adj. p < 0.05)

Top Associated Diseases

Autism spectrum disorder Autism spectrum disorder Parkinson disease Asthma Alzheimer disease

Disease Association Heatmap

-Log10(P-value) of disease gene enrichment per cell type.

Top Disease Associations

Dot size: overlap genes. Color: significance.

📥 Disease Enrichment Data

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Full Analysis ReportComprehensive Summary & Downloads

📊

Interactive HTML Report

Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.

📄 Open Report

📦

Download All Results

Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.

📥 Download ZIP

🔗

Share Results

Use this permanent link to share these analysis results:


                analysis.php?SP_ID=SP239&tisID=sys01tis16

📁 Available Result Files

Analysis	File	Type	Action
Cell Communication	cellchat_heatmap.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_network.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_pathway_dotplot.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_interactions.csv	Data (CSV)	📥 Download
Cell Communication	cellchat_pathway_summary.csv	Data (CSV)	📥 Download
GRN Analysis	grn_tf_heatmap.png	Figure (PNG)	🔍 View
GRN Analysis	grn_network.png	Figure (PNG)	🔍 View
GRN Analysis	grn_tf_activity.csv	Data (CSV)	📥 Download
GRN Analysis	grn_tf_targets.csv	Data (CSV)	📥 Download
Co-expression	coexp_dendrogram.png	Figure (PNG)	🔍 View
Co-expression	coexp_module_heatmap.png	Figure (PNG)	🔍 View
Co-expression	coexp_modules.csv	Data (CSV)	📥 Download
Co-expression	coexp_eigengenes.csv	Data (CSV)	📥 Download
DEG Analysis	deg_volcano.png	Figure (PNG)	🔍 View
DEG Analysis	deg_marker_heatmap.png	Figure (PNG)	🔍 View
DEG Analysis	deg_top_markers.csv	Data (CSV)	📥 Download
DEG Analysis	deg_significant.csv	Data (CSV)	📥 Download
DEG Analysis	deg_all_results.csv	Data (CSV)	📥 Download
Disease	disease_heatmap.png	Figure (PNG)	🔍 View
Disease	disease_dotplot.png	Figure (PNG)	🔍 View
Disease	disease_enrichment.csv	Data (CSV)	📥 Download
Report	sys01tis16_analysis_report.html	Report (HTML)	📄 Open
Report	sys01tis16_summary.json	Summary (JSON)	📥 Download